Gastric acid secretion of normal Japanese subjects in relation to Helicobacter pylori infection, aging, and gender

Iijima, Katsunori; Ohara, Shuichi; Koike, Tomoyuki; Sekine, Hitoshi; Shimosegawa, Tooru

doi:10.1080/00365520410005911

Cited by 63 publications

(47 citation statements)

References 43 publications

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“…[18][19][20][21][22][23][24][25] The prevalence of H. pylori infection is generally supposed to increase with age. 26 More recently, it was reported in Japan, that the prevalence of positive rate of serum anti-H. pylori-IgG as well as H. pylori infection detected histological and by the 13 C-urea breath test is decreasing in longliving elderly, leading to a concomitant decrease of Helicobacter pylori virulence factors A Soltermann et al the prevalence of gastric cancer in subjects older than 85 years. 27 Concerning IM, the authors reported an increase with age in either H. pylori-negative or -positive patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age

et al. 2007

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The histological parameters of Helicobacter pylori (H. pylori) gastritis are dependent on the virulence factor profile of the microbe, which includes the cytotoxins vacA (vacuolating cytotoxin A) and cagA (cytotoxinassociated gene A) as well as the duration of infection. The virulence factor genotypes vacA and cagA were assessed by the line probe reverse hybridization assay INNO-LiPA and correlated with the histological parameters of H. pylori infection, in particular intestinal metaplasia (IM) as well as with the patient's age. A total of 120 patients were analyzed; 47 patients with IM in the antrum and 73 control patients without this alteration. The vacA s1 cagA þ genotype (high virulence) correlated with the presence of antral IM, a more intense acute inflammation in both antrum and corpus and the formation of ulcer. The vacA m1 genotype (high virulence) correlated with a more intense acute inflammation in only the corpus as well as more prominent Russell bodies in the antrum. H. pylori strains with the vacA s2 m2 cagAÀ genotype (low virulence) were rarely found in these conditions (all P o0.05). No correlation with the virulence status was found for the type and extent of IM, the intensity of chronic inflammation, the formation of lymphoid follicles and the microbial density. Furthermore, patients with IM were 7 years older than their counterparts without (Po0.05). Finally, there was a trend for more virulent vacA s1 m1 cagA þ strains to be found in younger individuals (P40.05). The virulence genotype of the microbe is an important determinant for the severity of the gastritis and the formation of antral IM. Age is an additional factor for the development of IM. Keywords: Helicobacter; virulence; gastritis; histology; resistance The Gram-negative bacteria Helicobacter pylori colonize the human stomach. 1 Prolonged infection is associated with several diseases like chronic gastritis, peptic ulcer disease and stomach carcinoma or lymphoma. This association depends on bacterial, host and environmental factors. Among the bacterial factors, several virulence proteins determine the severity of inflammation and the formation of intestinal metaplasia (IM). [2][3][4][5] The most studied virulence proteins are vacA and cagA, which are injected into the gastric epithelial cell through a multimeric protein complex. 6 This protein complex is elaborated from the PAI (pathogenicity-island), a 40 kb DNA segment. CagA makes part of the PAI and targets particularly the phosphorylation cascade and the tight junctions. 7-9 H. pylori are either cagA-positive or -negative. VacA, present in all H. pylori, is located outside the PAI and forms an oligomeric pore with channel activity. 10,11 VacA has two variable parts: The s (signal peptide) region exists as allele s1 or s2. The m (middle) region occurs as m1 or m2 allelic type. The allele combination s1 m1 confers high, s1 m2 intermediate and s2 m2 low toxin activity. Most vacA s1 strains are cagA-positive, thus the two markers are closely related. 12 H. pylori infection is normal...

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Section: Discussionmentioning

confidence: 99%

Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age

et al. 2007

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“…In Japan and China, gastric adenocarcinoma is very common because, firstly, nearly all strains are of the most virulent pro-inflammatory cagApositive cytotoxic type and secondly because such strains usually cause a pan-or corpus-predominant gastritis in these populations with associated reduced acid secretion. 11 Thus in these populations, H. pylori would be expected more predictably to have a negative association with GORD and its complications, Barrett's oesophagus and oesophageal adenocarcinoma. This is indeed the case: studies from these countries consistently show a strong negative association.…”

Section: H Pylori and Gord Complications In East Asiamentioning

confidence: 98%

Does Helicobacter pylori protect against oesophageal adenocarcinoma, and if so, how?

Atherton

2008

Clinical Medicine

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“…Feldman et al studied gastric acid secretion in elderly patients and found that basal acid output and peak acid output did not correlate with age (Feldman&Cryer, 1998). Similarly, Lijima et al, reported that gastric acid secretion was well preserved irrespective of ageing, however it seemed to increase with ageing in the H. pylori-negative subjects (Iijima et al, 2004). The decline in gastric acid secretion in H. pylori-positive patients depends on both an increasing prevalence of fundic atrophic gastritis and inflammatory cytokines, i.e., interleukin (IL) IL-1 and TNF-, which are known to inhibit parietal cells.…”

Section: Gastric Acid Secretionmentioning

confidence: 99%

Helicobacter pylori Infection in Elderly Patients

Salles

2011

Peptic Ulcer Disease

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Gastric acid secretion of normal Japanese subjects in relation to Helicobacter pylori infection, aging, and gender

Cited by 63 publications

References 43 publications

Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age

Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age

Does Helicobacter pylori protect against oesophageal adenocarcinoma, and if so, how?

Helicobacter pylori Infection in Elderly Patients

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