Gastric acid secretion in the chicken: Effect of histamine H2 antagonists and H+/K+-ATPase inhibitors on gastro-intestinal pH and of sexual maturity calcium carbonate level and particle size on proventricular H+/K+ ATPase activity

Guinotte, F.; Gautron, Joël; Soumarmon, Annick; Robert, J; Péranzi, Gabriel; Nys, Yves

doi:10.1016/0300-9629(93)90520-e

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…The antisecretory effect of omeprazole confirmed in vivo the involvement of the H',K+ ATPase in the process of acid secretion in birds as shown in mammals. The existence of H+,K+ ATPase activity in proventricular extract in vitro (Guinotte et al 1993) supports this hypothesis. Proventricular acid secretion is collected in the gizzard, as reflected by the high correlation between their pH values ( Table 5), and induces Ca solubilization.…”

Section: Discussionsupporting

confidence: 67%

“…Nevertheless, it enhanced the amount of soluble Ca in the gizzard and duodenum of pullets to a higher extent than in laying hens ( Table 4). The higher proton concentration observed in the gizzard supernatant fraction in immature pullets compared with hens (Nys & Cabrera-Saadoun, 1986) and the slightly higher H+,K+ ATPase activity observed in pullets (Guinotte et al 1993) might explain this observation. Moreover, disappearance of soluble Ca is slower in pullets because of a lower intestinal Ca absorption.…”

Section: Discussionmentioning

confidence: 80%

“…The levels of insoluble Ca in the gizzard tended to increase with the Ca consumption and were similar in immature pullets and laying hens. There is, therefore, no evidence that sexual maturity is associated with any stimulation of acid secretion as confirmed by the absence of increase in H+,K' ATPase activity in hens compared with pullets (Guinotte et al 1993).…”

Section: Discussionmentioning

confidence: 93%

“…Moreover, laying diets include coarse particles of Ca in substitution of 50-66% of fine particles to improve eggshell quality (Guinotte, 1992). These increases in amount and size of CaCO, in poultry, when compared with other species, might reveal a prominent role of gastric acid secretion in Ca solubilization and might affect the acid secretion as suggested by a higher in vitro activity of H+,K+-transporting ATPase (EC 3.6.1 .36) in hens receiving coarse particles of Ca (Guinotte et al 1993). In humans, such an increase in Ca input (Behar et al 1977) and * For reprints.…”

mentioning

confidence: 99%

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Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

Guinotte¹,

Gautron²,

Nys³

et al. 1995

Br J Nutr

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In chicks, immature pullets and laying hens, the inhibition of gastric acid secretion by omeprazole, an H+,K+-transporting ATPase (EC 3.6.1.36) inhibitor, greatly increased proventricular and gizzard pH values. Consequently, gizzard soluble Ca concentration deceased and the insoluble Ca fraction increased. Inhibition of acid secretion increased duodenal pH values in immature pullets and laying hens but not in chicks. Duodenal soluble and ionic Ca concentrations were lowered by gastric acid inhibition in chicks and to a larger extent in immature pullets and laying hens. The use of Ca of coarse particle size increased the gizzard insoluble Ca fraction in chicks and pullets. However, it did not influence its soluble Ca fraction in chicks but tended to reinforce the negative effect of omeprazole on soluble Ca in the gizzard and duodenum of chicks and laying hens. Coarse particles of Ca led to an increase in gizzard and duodenal soluble Ca at the end of eggshell calcification in laying hens. An enhancement in the level of Ca in the diet from 10 to 36 g/kg increased gizzard soluble Ca and duodenal soluble and ionic Ca concentrations in immature and adult hens. Intestinal Ca retention and bone mineralization was unaffected by gastric acid inhibition in chicks but were largely diminished by the use of coarse particles of Ca. Gastric acid inhibition was associated in laying hens with decreased Ca retention to a small extent and with reduced eggshell quality. These observations confirm that gastric acid secretion is of importance for CaCO, solubilization but question its role as a prerequisite for intestinal Ca retention in chicks and even in hens fed on a high Ca diet.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

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Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

Guinotte¹,

Gautron²,

Nys³

et al. 1995

Br J Nutr

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“…The ventriculus is again variable in birds depending on diet and species, but it is acidic, typically in the range of 3.6-4.4 (Guinotte et al 1993). This acidity, combined with grinding activity and ventriculus residence time of up to 4 or more weeks, would be predicted to mobilize Pb.…”

Section: Discussionmentioning

confidence: 99%

Dosing of adult pigeons with as little as one #9 lead pellet caused severe δ-ALAD depression, suggesting potential adverse effects in wild populations

Holladay¹,

Nisanian²,

Williams³

et al. 2012

Ecotoxicology

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Avian wildlife species commonly ingest lead (Pb) spent shot or bullet fragments as grit or mistakenly as food. In previous studies in our laboratory and others, the toxicity varied based on the diet as well as type and quantity of Pb ingested. In the current study, domestic pigeons were gavaged with 1, 2, or 3 Pb pellets and then followed with weekly radiographs and blood physiologic endpoints for 28 days. Pellet retention decreased by roughly 50 % per week as pellets were either absorbed or excreted, except for week 4 where pellet number no longer was diminished. Size of retained pellets visually decreased over retention time. Birds dosed with a single #9 pellet showed mean blood Pb levels over 80 times higher than those of the controls, verifying Pb pellet absorption from the gut. A single Pb pellet also reduced plasma δ-aminolevulinic acid dehydratase (δ-ALAD) activity by over 80 % compared to controls, suggesting the potential for population injury in Pb pellet-exposed pigeons.

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Appendix II: Formulary for Common Wildlife Species

Barron

2019

Medical Management of Wildlife Species

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Gastric acid secretion in the chicken: Effect of histamine H2 antagonists and H+/K+-ATPase inhibitors on gastro-intestinal pH and of sexual maturity calcium carbonate level and particle size on proventricular H+/K+ ATPase activity

Cited by 13 publications

References 40 publications

Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

Dosing of adult pigeons with as little as one #9 lead pellet caused severe δ-ALAD depression, suggesting potential adverse effects in wild populations

Appendix II: Formulary for Common Wildlife Species

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