Gastric acid secretion in L-histidine decarboxylase–deficient mice

Tanaka, Satoshi; Hamada, Kiyomi; Yamada, Noboru; Sugita, Yuko; Tonai, Shunsuke; Hunyady, Béla; Palkovits, Miklós; Falus, András; Watanabe, Takehiko; Okabe, Susumu; Ohtsu, Hiroshi; Ichikawa, Atsushi; Nagy, András

doi:10.1053/gast.2002.30312

Cited by 79 publications

(42 citation statements)

References 32 publications

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“…The present study also revealed that although HDC Ϫ/Ϫ mice lack gastric mucosal histamine, such mice exhibit increased parietal cell sensitivity to exogenous histamine, which results in enhanced acid secretion. Although Tanaka et al (2002) demonstrated slightly reduced basal acid secretion in HDC Ϫ/Ϫ mice , the present study found that intragastric pH was significantly higher in HDC Ϫ/Ϫ mice compared with wild-type mice. In addition, serum gastrin levels in HDC Ϫ/Ϫ mice were also significantly higher than those of wild-type mice, a result of the increased pH (data not shown).…”

Section: Discussioncontrasting

confidence: 80%

“…Tanaka et al (2002) mice. Gastric acid secretion was measured with the gastric fistula method under urethane anesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…Ϫ/Ϫ mice, as well as control wildtype littermate mice, were generated on a mixed genetic 129/Sv ϫ ICR background (Ohtsu et al, 2001;Tanaka et al, 2002) and raised until 10 to 12 weeks old. The animals were housed at 23°C with 13 h of light (7:00 AM-8:00 PM).…”

Section: Animals Male and Female Hdcmentioning

confidence: 99%

“…These findings suggest that ␣-FMH treatment is not sufficient to eliminate histamine's influence on gastric secretion. HDC Ϫ/Ϫ mice were recently generated by gene-targeting methods (Ohtsu et al, 2001(Ohtsu et al, , 2002Tanaka et al, 2002). Such mice exhibited trace histamine levels and no de novo gastric mucosal histamine synthesis.…”

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confidence: 99%

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Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice

Furutani

Aihara

Nakamura

et al. 2003

J Pharmacol Exp Ther

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Histidine decarboxylase (HDC) represents the sole enzyme that produces histamine in the body. The present work investigated the role of endogenous histamine in carbachol-and gastrininduced gastric acid secretion with HDC-knockout (HDC Ϫ/Ϫ ) mice. Acid secretion was measured in either mice subjected to acute fistula production under urethane anesthesia or conscious mice that had previously undergone pylorus ligation. In wild-type mice, carbachol and gastrin significantly stimulated acid secretion, increasing gastric mucosal histamine. In contrast, in HDC Ϫ/Ϫ mice, carbachol and gastrin had little impact when either delivered alone or together. Nonetheless, the two agents achieved a synergistic effect when delivered together with exogenous histamine, stimulating acid secretion in HDC Ϫ/Ϫ mice. Such synergism was abolished by the histamine H 2 -receptor antagonist famotidine. cAMP involvement in acid secretion was also examined with theophylline, a phosphodiesterase inhibitor, and forskolin, an adenylate cyclase activator.In wild-type mice, theophylline significantly increased acid secretion, enhancing carbachol-and gastrin-stimulated acid secretion. In contrast, in HDC Ϫ/Ϫ mice, theophylline failed to exert an effect on basal acid secretion, as well as carbachol-and gastrin-stimulated acid secretion. Although forskolin interacted with carbachol, allowing acid secretion in HDC Ϫ/Ϫ mice, similar results were not achieved with gastrin. Such results suggest that 1) histamine is essential for carbachol-and gastrin-stimulated gastric acid secretion in mice; and 2) histamine-induced cAMP production contributes to the in vivo response to carbachol or gastrin.

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Section: Discussioncontrasting

confidence: 80%

“…Tanaka et al (2002) mice. Gastric acid secretion was measured with the gastric fistula method under urethane anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Section: Animals Male and Female Hdcmentioning

confidence: 99%

mentioning

confidence: 99%

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Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice

Furutani

Aihara

Nakamura

et al. 2003

J Pharmacol Exp Ther

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“…[21][22][23] H 1 Rs are involved in mediating sensorineural signaling and vascular dilatation. 24 Activation of H 1 R is known to regulate food and water intake and diurnal feeding rhythm.…”

Section: Overview Of Histamine and Histamine Receptors In The Gastroimentioning

confidence: 99%

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Fabisiak

Włodarczyk

Fabisiak

et al. 2017

J Neurogastroenterol Motil

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Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

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Histamine Biosynthesis and Function

Ichikawa

Tanaka

2012

Encyclopedia of Life Sciences

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Histamine is one of the essential biogenic amines that mediate a wide variety of physiological and pathological responses, such as inflammation, gastric acid secretion, neurotransmission and immune modulation. Histamine is synthesised through decarboxylation of l ‐histidine and functions by acting on its specific receptors consisting of H 1 , H 2 , H 3 and H 4 subtypes. Mast cells and basophils store histamine in their cytoplasmic granules and release it when stimulated, whereas histamine release is closely associated with its de novo synthesis in gastric enterochromaffin‐like cells, and neurons. A series of antagonists targeting H 1 and H 2 subtype has brought about enormous success to therapies for immediate allergy and peptic ulcer, respectively. The H 3 subtype has been focused on as the therapeutic target for cognitive dysfunctions, because it is expressed preferentially in neurons and modulates the neurotransmitter release. Recently identified H 4 subtype is expressed preferentially in blood cells and mediates their chemotaxis in response to histamine. Key Concepts: Histamine mediates a wide variety of physiological and pathological responses, such as inflammation, gastric acid secretion, neurotransmission and immune modulation. Histamine is synthesised through decarboxylation of l ‐histidine by histidine decarboxylase and is catabolised through oxidative deamination or methylation. Tissue histamine levels are transiently increased by degranulation of mast cells and basophils while they are upregulated by de novo synthesis in gastric enterochromaffin‐like cells, and neurons. Histamine exerts its functions by acting on its specific receptors consisting of H 1 , H 2 , H 3 and H 4 receptors. Histamine is a paracrine mediator, of which actions are generally limited in the local microenvironment. Histamine H 1 receptor antagonists have brought successful therapeutic approaches for immediate allergy, because histamine evokes vasodilation and increased vascular permeability by acting on the H 1 receptor. In the central nervous system, histamine is involved in awakening, appetite, maintenance of circadian rhythm, learning and memory, which are regulated by the H 1 and H 3 receptors. Histamine stimulates parietal cells to induce gastric acid secretion by acting on the H 2 receptor, of which antagonists drastically improved therapeutic approaches for peptic ulcer. Pre‐synaptic histamine H 3 receptor regulates release of various neurotransmitters including histamine itself, and is expected as a potential drug target for the treatment of cognitive dysfunctions. Histamine H 4 receptor is expressed exclusively in blood cells and mediates their chemotaxis in response to histamine.

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Gastric acid secretion in L-histidine decarboxylase–deficient mice

Cited by 79 publications

References 32 publications

Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice

Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Histamine Biosynthesis and Function

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