Gastric Acid Secretion in Chronic Iron-Deficiency Anaemia

The stomach in iron-deficiency anaemia.

“…In the paper by Stone (1968) nine out of 21 patients showed an increase in acid secretion on retesting at five to seven months. The findings in these papers confirm and extend previous work on the subject (Delamore and Shearman, 1965;Shearman, Delamore, and Gardner, 1966;Jacobs, Lawrie, Entwistle, and Campbell, 1966). However, the conclusions reached in the two papers are open to other interpretations.…”

Gastric secretory response to iron therapy.

“…The introduction of maximal histamine stimulation (Kay, 1953) showed that the older methods gave no accurate indication of the presence of achlorhydria, but workers using the augmented histamine test have also reported a return of acidity in similar circumstances, although still using Topfer's reagent as a criterion (Davidson and Markson, 1955;Brumfitt, 1960). Accurate measurements of acid secretion have recently been made by Shearman, Delamore, and Gardner (1966) and by Jacobs, Lawrie, Entwistle, and Campbell (1966), and have shown that maximal acid output (M.A.O.) increased after iron therapy in a number of patients.…”

Effect of gastric juice on iron absorption in patients with gastric atrophy.

“…In iron-deficiency anaemia impaired iron absorption is found in those subjects with gastric atrophy (Goldberg et al, 1963;Jacobs, Lawrie, Entwistle, and Campbell, 1966a). A similar impairment is found in anaemic rats after gastrectomy (Rieber, Conrad, and Crosby, 1967) and this is due to loss of a factor in the gastric secretion (Murray and Stein, 1967).…”