Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia

Slotta, Jan E.; Heine, Sabine; Kauffels, Anne; Krenn, Thomas; Grünhage, F; Wagner, Mathias; Graf, Norbert; Schilling, Martin K.; Schuld, Jochen

doi:10.1016/j.jpedsurg.2011.06.005

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Depending on the disease stage and condition, surgical, chemotherapy, and radiotherapy treatments are used for these patients. The only curative treatment for localized form of gastric adenocarcinoma is radical gastrectomy with lymph node dissection; however, recurrence is relatively common within two years after the treatment (7,10,11).…”

Section: Discussionmentioning

confidence: 99%

Advanced Gastric Adenocarcinoma in a 12-Year-Old Girl

2021

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Introduction: Gastric adenocarcinoma is extremely rare in children, and it is typically seen among the elderly in their sixth and seventh decades of life. There are few studies on the clinical manifestations, treatment, and prognosis of this malignancy in children. Case Presentation: In this paper, we describe a 12-year-old girl presented with abdominal pain, anorexia, nausea, and abdominal distension. A high volume of ascites was reported in ultrasound and computed tomography (CT) scan of the abdomen and pelvis. The patient underwent endoscopy and biopsy of the gastric mucosa. The histopathological findings were positive for gastric adenocarcinoma. Unfortunately, the patient died two months after chemotherapy because she was at the advanced stage of the disease. Conclusions: Although gastric adenocarcinoma is rare in children, it should be considered in patients with persistent upper gastrointestinal symptoms.

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Section: Discussionmentioning

confidence: 99%

Advanced Gastric Adenocarcinoma in a 12-Year-Old Girl

2021

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“…Our review of the literature identified 42 published cases of pediatric GAC, with 21 of these cases published in the past decade. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] at diagnosis of the most recent 21 cases ranged from 21 months to 17 years, with a mean of 11.7 years. Twelve of these patients were males.…”

Section: Discussionmentioning

confidence: 99%

“…GAC etiology, as described in adult studies, involves an interplay of factors, including environmental (alcohol consumption, smoking, high dietary intake of salt and nitroso compounds, and a low-fiber diet), host, and infectious (H pylori, Epstein-Barr virus). 1 Four of the 8 patients tested were diagnosed with H pylori infection, [1][2][3][4] all of whom were of Middle Eastern descent where H pylori is known to be endemic. Here we describe GAC in a 17-yearold who presented without any of these associated factors.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, 2 of the cases identified were in children with agammaglobulinemia, a condition that predisposes to malignancy. 3,5 Of note, 5 of the patients had a strong family history of malignancy suggesting the possibility of genetic inheritance in carcinogenesis. Unfortunately, no genetic testing was performed in those instances.…”

Section: Discussionmentioning

confidence: 99%

“…The presenting symptoms of the described cases of GAC were typically nonspecific, including abdominal pain, vomiting, fatigue, and weight loss. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Three patients presented with dyspnea, pulmonary hypertension, and subsequent insufficiency from pulmonary tumor thrombotic microangiopathy. 7,9,10 Hematologic findings most commonly included iron deficiency anemia; however, 2 cases of pernicious anemia and 1 case of hemolytic anemia were described.…”

Section: Discussionmentioning

confidence: 99%

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An Adolescent With Cough and Dyspepsia

Saliba

Cherrick

Wali

2015

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A 17-year-old Caucasian male previously healthy presents with a 4-month history of persistent dry cough, dyspnea with exertion, and dyspepsia. A chest X-ray showed no acute disease. Empiric asthma therapy with fluticasone was ineffective. He was treated for possible gastroesophageal reflux with ranitidine, followed by pantoprazole, still with no improvement in symptoms. Another chest X-ray was done for worsening nighttime cough and revealed bilateral patchy infiltrates, suggestive of atypical pneumonia. He was treated with 5 days of azithromycin with no clinical improvement. Due to his persistent dyspepsia and new-onset epigastric pain, he was referred to pediatric gastroenterology. An upper endoscopy revealed erythema of the distal esophagus and an ulcerated mass in the gastric fundus with diffuse congestion of the gastric body (Figure 1).The pathology results of the mass biopsy were consistent with a poorly differentiated adenocarcinoma, with positivity for CK7 CDX-2 and negative for chromogranin, confirming a tumor of gastric origin (Figures 2 and 3). Staining for CD34, CD31, and D-240 outlined multiple areas of lymphatic space invasion by tumor cells in the esophagus and the stomach. Immunohistochemistry studies were negative. Laboratory data included lactate dehydrogenase

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Malignancy in Predominantly Antibody Deficiencies (PAD)

Wehr

2018

Humoral Primary Immunodeficiencies

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Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia

Cited by 11 publications

References 22 publications

Advanced Gastric Adenocarcinoma in a 12-Year-Old Girl

Advanced Gastric Adenocarcinoma in a 12-Year-Old Girl

An Adolescent With Cough and Dyspepsia

Malignancy in Predominantly Antibody Deficiencies (PAD)

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