Gastrectomy with extended lymphadenectomy for primary treatment of gastric cancer

McCulloch, Peter; Niita, M. Eidi; Kazi, Hussain; Gama-Rodrigues, J. J.

doi:10.1002/bjs.4839

Cited by 103 publications

(55 citation statements)

References 39 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, the results from these meta-analysis have confirmed that the findings from those trials concerning morbidity and mortality can be formally accepted. The notion that mortality rates have been greatly reduced, based on the results from recent clinical trials on the surgical treatment of gastric cancer and that extended lymph node resection can be performed safely in experienced centers is unlikely to be valid 6,14,16,17,19 .…”

Section: Discussionmentioning

confidence: 99%

“…These studies involved 1549 patients, of whom 791 were allocated to the D1 surgical procedure, 617 to D2 and 141 to D3. A systematic review was conducted by McCulloch et al 6 , in 2005, including randomized and non-randomized comparisons between D1 and D2 gastrectomy for primary treatment of gastric cancer. The meta-analysis was performed separately; 15 separate studies were selected, comprising two randomized trials, two non-randomized comparisons and 11 cohort studies reporting results from one technique only.…”

Section: Included Studiesmentioning

confidence: 99%

“…The theoretical advantage in extended lymph node resection, such that it increases the chances for curative treatment, might be illusory if it is considered that these nodes may not be involved in the disease. Moreover, by extending the node dissection, the surgical treatment may substantially increase the morbidity and mortality 6,7,8 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer: meta-analysis of randomized clinical trials

et al. 2008

View full text Add to dashboard Cite

Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer. Meta-analysis of randomized clinical trials 1 Impacto da linfadenectomia ampliada na morbidade, mortalidade, recidiva e cinco anos de sobrevida após gastrectomia por câncer. Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer: meta-analysis of randomized clinical trials

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Lymphadenectomy is considered essential for gastric cancer surgery; however, the extent of lymph node removal is still debated in the literature [1][2][3][4][5][6]. In Asia, extended lymph node dissection has long been the standard of care for patients with advanced gastric cancer [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

A systematic review of spleen and pancreas preservation in extended lymphadenectomy for gastric cancer

et al. 2011

View full text Add to dashboard Cite

Background The overall prognosis and survival of patients with advanced gastric cancer are generally poor. Extended lymphadenectomy is recommended for patients with advanced gastric cancer; however, splenectomy and distal pancreatectomy performed with an extended lymph node dissection may be associated with increased morbidity and mortality. Method Electronic literature searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from 1 January 1998 to 31 December 2009. Studies on gastric carcinoma investigating extended lymphadenectomy with splenectomy and/or pancreaticosplenectomy that reported data on surgical outcomes or survival were selected. Results Forty studies were included in this review. Decreased complication rates were demonstrated with spleen preservation in two prospective studies and three retrospective studies, and with pancreas preservation in five retrospective studies. No randomized controlled trial showed survival benefit or detriment for preservation of spleen or pancreas in extended lymphadenectomy. Improved survival was demonstrated with spleen preservation in two prospective and eight retrospective studies, and with pancreas preservation in one prospective and four retrospective studies. Conclusions Preservation of the spleen and pancreas during extended lymphadenectomy for gastric cancer decreases complications with no clear evidence of improvement or detriment to overall survival.

show abstract

“…Пятилетняя выживаемость больных РРЖ после радикаль-ного хирургического лечения варьирует в пределах 85-95%, что значительно превышает таковую при РЖ с глубиной инвазии Т2 и более [5,6]. Благоприятный прогноз обусловлен низкой ча-стотой лимфогенного и гематогенного метастазирования при РРЖ.…”

unclassified

Current approaches to the diagnosis and treatment of early gastric cancer

Ryabov¹,

Соколов²,

Khomyakov³

et al. 2015

Onkol. Z. im. P.A. Gercena

View full text Add to dashboard Cite

Рассмотрено современное состояние проблемы диагностики и лечения раннего рака желудка. Описаны различные ме-тоды эндоскопического исследования желудка, в том числе основанные на различных физических методах улучшения визуализации. Дана оценка предикторам лимфогенного метастазирования. На основании данных крупных клинических исследований сформулированы показания и противопоказания к различным видам хирургического лечения раннего рака желудка (эндоскопическим, малоинвазивным, открытым операциям). Ключевые слова: ранний рак желудка, эндоскопическая диагностика и лечение, предикторы лимфогенного метастазиро-вания, хирургическое лечение.The paper considers the state-of-the-art of the diagnosis and treatment of early gastric cancer. It describes various gastric endoscopic techniques, including those based on different physical methods for imaging improvement. The predictors of lymphatic cancer spread are assessed. Based on the data of large clinical trials, the authors formulated indications for and contraindications to different surgical treatment options (endoscopic, minimally invasive, open-access operations) for early gastric cancer.Key words: early gastric cancer, endoscopic diagnosis and treatment, predictors of lymphatic cancer spread, surgical treatment.

show abstract

Gastrectomy with extended lymphadenectomy for primary treatment of gastric cancer

Abstract: Evidence for D2 dissection is inconclusive. No overall survival advantage has emerged, but some patients with intermediate stage disease may benefit. Excess operative mortality appears to be associated with pancreatico-splenectomy, low case volume and lack of specialist training.

Cited by 103 publications

References 39 publications

Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer: meta-analysis of randomized clinical trials

Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer: meta-analysis of randomized clinical trials

A systematic review of spleen and pancreas preservation in extended lymphadenectomy for gastric cancer

Current approaches to the diagnosis and treatment of early gastric cancer

Contact Info

Product

Resources

About