The case presented here is one of emphysematous cholecystitis with process extension through the gallbladder into the liver, necrosis of the liver and septicemia that caused the patient’s death. In the literature that presents cases of emphysematous cholecystitis, the course of the disease is described to be benign, with a death rate of 15 %. In all the cases, the gangrenous and emphysematous process did not extend beyond the gallbladder or, after perforation of the peritoneum, cholecystectomy led to complete recovery. The infectious process caused by Clostridium bacteria is not restricted to the gallbladder. In case of a diagnosis or treatment delay, the infection might penetrate and extend rapidly to the liver and subsequently cause the patient’s death. The possibility of such a process development, in cases of emphysematous cholecystitis is considered a strong argument for emergency surgery, in any suspected case of cholecystitis.