Gaseous Exchange During Endotracheal Ventilation for Asphyxia at Birth

Abstract

AND 2.5 KG.ADULT RABBIT ANAESTHETIZED I 0 0 1 4 MINUTES AFTER LAST SPONTANEOUS GASP 1 0 2 4 6 8 1 0 0 4 8 d MIN. FIG. 2Record of gas uptake and respiratory response during the resuscitation of an asphyxiated adult rabbit. A plot summarizing the changes in heart rate has been superimposed. (Note that the time scale is 1/3 of that used in Figures 3 and 4.)

Pulmonary gas exchange immediately after birth in spontaneously breathing infants.

“…Studies of the pulmonary gas exchange at birth include both of these aspects, but they have been performed in only a very few earlier studies with conflicting results, and not in spontaneously as well as artificially breathing neonates.1 2 Studies of the oxygen uptake during and immediately after ventilation on an endotracheal tube have also been performed by the use of a closed system. [3][4][5] The aim of the present investigation was therefore to study the pulmonary gas exchange and primarily the rate of carbon dioxide production (co2) in spontaneously breathing newborn infants delivered vaginally and after elective caesarean section. It was also considered important to study the changes in transcutaneously measured oxygen saturation and in heart rate in connection with changes in ventilation.…”

Perinatal cardiac arrest. Quality of the survivors.

“…Sporadic reports of cases of successful external cardiac massage in the neonatal period, with some information concerning the subsequent progress of the babies concerned, have appeared during the past 12 years (Moya et al, 1962;Surks and Ladner, 1962;Gallagher and Neligan, 1962;Mathews, Avery, and Jude, 1963;Hey and Kelly, 1968). But we have seen no report of any series of cases which makes it possible to assess the prognosis realistically.…”

The oxygen uptake and pulmonary blood flow during resuscitation from asphyxia in foetal and adult sheep

“…in the open-chest experiments, did show unequivocally the slow rise of oxygen consumption reported by Hey & Kelly (1968) when the degree of asphyxia was severe enough. The evidence is that pulmonary blood flow in these preparations is the limiting factor giving rise to this phenomenon.…”

“…This phenomenon had been conspicuously absent in the adult rabbit experiments undertaken as part of the development of Hey & Kelly's (1968) apparatus, so investigations of adults of the same species were also undertaken as a more valid direct comparison offoetal and adult behaviour.…”

“…In a study of the resuscitation of asphyxiated new-born infants, Hey & Kelly (1968) designed apparatus which was used both to supply Intermittent Positive Pressure Ventilation (IPPV) and to measure the gas * College of Medicine, University of Florida. t Department of Obstetrics and Gynaecology, The Queen Elizabeth Hospital, Birmingham. Phy. 205 I4 D. P. G. BOLTON AND OTHERS uptake and tidal volume during resuscitation.…”