Gaseous chemical compounds in indoor and outdoor air of 602 houses throughout Japan in winter and summer

Uchiyama, Shigehisa; Tomizawa, Takuya; Tokoro, Asumo; Aoki, Manami; Hishiki, Mayu; Yamada, T.; Tanaka, Reiko; Sakamoto, Hironari; Yoshida, Tsutomu; Bekki, Kanae; Inaba, Yohei; Nakagome, Hideki; Kunugita, Naoki

doi:10.1016/j.envres.2014.12.005

Cited by 88 publications

(55 citation statements)

References 31 publications

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“…In homes in Australia, the mean and maximum FA concentration was 15 and 46 µg/m 3 , respectively (Lazenby et al 2012). In homes in Japan, the mean and maximum concentration was 13 and 58 µg/m 3 , respectively, in the winter and in the summer 34 and 220 µg/m 3 , respectively, with 0.7 % exceeding 100 µg/m 3 (Uchiyama et al 2015). In Korea, in newly built apartments at the pre-occupancy stage, the mean, the 95th percentile and the maximum FA concentration was 61, 110 and 160 µg/m 3 , respectively (Shin and Jo 2012).…”

Section: Introductionmentioning

confidence: 99%

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

2016

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In 2010, the World Health Organization (WHO) established an indoor air quality guideline for short- and long-term exposures to formaldehyde (FA) of 0.1 mg/m3 (0.08 ppm) for all 30-min periods at lifelong exposure. This guideline was supported by studies from 2010 to 2013. Since 2013, new key studies have been published and key cancer cohorts have been updated, which we have evaluated and compared with the WHO guideline. FA is genotoxic, causing DNA adduct formation, and has a clastogenic effect; exposure–response relationships were nonlinear. Relevant genetic polymorphisms were not identified. Normal indoor air FA concentrations do not pass beyond the respiratory epithelium, and therefore FA’s direct effects are limited to portal-of-entry effects. However, systemic effects have been observed in rats and mice, which may be due to secondary effects as airway inflammation and (sensory) irritation of eyes and the upper airways, which inter alia decreases respiratory ventilation. Both secondary effects are prevented at the guideline level. Nasopharyngeal cancer and leukaemia were observed inconsistently among studies; new updates of the US National Cancer Institute (NCI) cohort confirmed that the relative risk was not increased with mean FA exposures below 1 ppm and peak exposures below 4 ppm. Hodgkin’s lymphoma, not observed in the other studies reviewed and not considered FA dependent, was increased in the NCI cohort at a mean concentration ≥0.6 mg/m3 and at peak exposures ≥2.5 mg/m3; both levels are above the WHO guideline. Overall, the credibility of the WHO guideline has not been challenged by new studies.

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Section: Introductionmentioning

confidence: 99%

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

2016

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“…2016). Levels of NO 2 tend to rise in winter, with decreased ventilation in apartments, as well as the more frequent use of gas stoves for cooking and as a supplement for home heating (Uchiyama et al 2015). In our earlier source modeling analyses of indoor pollutants in this study (Habre et al 2014b), we found that cooking was a significant predictor of indoor NO 2 levels, followed by outdoor NO 2 levels concentrations, confirming that use of gas stoves for cooking and infiltration of outdoor NO 2 (associated with traffic and fuel combustion in our study area) contributed to indoor NO 2 levels.…”

Section: Discussionmentioning

confidence: 99%

Indoor air pollution and respiratory health effects in inner city children with moderate to severe asthma

Schachter

Rohr

Habre

et al. 2020

Air Qual Atmos Health

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Indoor air pollution is increasingly recognized as a significant risk for respiratory illness, particularly in vulnerable populations. Thirty-six children aged 6-14 years with moderate/severe asthma from inner city areas in New York City were studied for 2-week periods (summer and winter) using diaries and spirometry. Seven-day integrated indoor samples of PM 10 , PM 2.5 , trace elements, elemental/organic carbon, black carbon, and criteria gases (NO 2 , SO 2 , and O 3 ) were collected in the subjects' residences. Asthma outcomes included cough and wheeze severity, albuterol use, and pulmonary function. Mixed effects regression models for longitudinal data were used to relate weekly indoor pollutant concentrations to asthma outcomes. Odds ratios (ORs) were calculated for ordinal outcomes. During winter, significant positive associations for average weekly symptom severity scores were seen for NO 2 (OR = 2.83; p = 0.02), calcium (OR = 3.29; p = 0.02), and silicon (OR = 3.64; p = 0.04). In summer, chlorine was associated with average weekly symptom scores (OR = 1.85; p = 0.004). Average albuterol puff use per day in winter was associated with NO 2 (OR = 5.89; p = 0.009), nickel (OR = 2.27; p = 0.05), and silicon (OR = 5.59; p = 0.05). Albuterol use was not associated with indoor pollutants in summer. Asthma severity was associated with specific indoor pollutants. Seasonal differences were observed by pollutant and by clinical index studied.

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“…As a study in France showed, the nitrogen dioxide concentration in indoor air particularly increased only during winter and was well correlated with the formic acid concentration [49]. In addition, inadequate and poorly designed ventilation in crowded places may boost exposure to air-borne pathogens by increasing their concentration in stagnant air and by re-circulating contaminated air.…”

Section: Discussionmentioning

confidence: 99%

Assessing Effect Modification of Excess Winter Death by Causes of Death and Individual Characteristics in Zhejiang Province, China: A Multi-Community Case-Only Analysis

Zhang

Ren

et al. 2018

IJERPH

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Mortality in many parts of the world has a seasonal pattern, with a marked excess of deaths during winter. To date, however, there is very little published evidence on the nature of this wintertime excess in low- and middle-income countries. In this study, we aimed to quantify the extent of the death peak in winter and to assess effect modification on excess winter death (EWD) by individual characteristics and cause of deaths in China. We used a Cosinor model to examine seasonal patterns for specific causes of deaths and a case-only analysis of deaths in winter compared with other seasons to assess effect modification by individual characteristics. A total of 398,529 deaths were investigated between January 2010 and December 2013 in Zhejiang Province, China. Deaths peaked in winter, and overall mortality was around 30% higher in winter than in summer. Although diseases of the respiratory and circulatory systems were highly seasonal, surprisingly we observed that deaths from mental and behavioral disorders exhibited greater fluctuation. Males, the elderly and illiterate individuals suffered high EWD. EWDs were also particularly common in emergency rooms, at home, on the way to hospitals, and in nursing homes/family wards. This study highlighted the high EWD in some previously unreported groups, indicating new information to facilitate the targeting of necessary preventive measures to those at greatest risk in order to mitigate wintertime death burdens.

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Gaseous chemical compounds in indoor and outdoor air of 602 houses throughout Japan in winter and summer

Cited by 88 publications

References 31 publications

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

Indoor air pollution and respiratory health effects in inner city children with moderate to severe asthma

Assessing Effect Modification of Excess Winter Death by Causes of Death and Individual Characteristics in Zhejiang Province, China: A Multi-Community Case-Only Analysis

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