Gas sensor arrays for early detection of infection in mammalian cell culture

Bachinger, Thomas; Riese, U.; Eriksson, Rolf; Mandenius, Carl Fredrik

doi:10.1016/s0956-5663(01)00315-3

Cited by 25 publications

(9 citation statements)

References 8 publications

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“…The shaded area represents the range of values, in which the culture is in its "normal" state. inated fed-batch stayed more or less unaffected, whilst most of the variance was captured by EN signals, corroborating the fact that the EN is a powerful tool for detecting a microbial contamination (Bachinger et al, 2002;Komaraiah et al, 2004).…”

Section: Generation Of Trajectories From On-line Nir and En Data In Fmentioning

confidence: 54%

On-line multi-analyzer monitoring of biomass, glucose and acetate for growth rate control of a Vibrio cholerae fed-batch cultivation

Navrátil

Norberg²,

Lembrén³

et al. 2005

Journal of Biotechnology

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Section: Generation Of Trajectories From On-line Nir and En Data In Fmentioning

confidence: 54%

On-line multi-analyzer monitoring of biomass, glucose and acetate for growth rate control of a Vibrio cholerae fed-batch cultivation

Navrátil

Norberg²,

Lembrén³

et al. 2005

Journal of Biotechnology

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“…For example, a process performance trajectory can be created that depicts the process course and captures the repeatability of the process (Cimander and Mandenius, 2004). -Similar to this are software sensors which detect unwanted conditions of the culture, such as contamination or infection (Bachinger et al, 2002), the loss of plasmids (Bachinger et al, 2001), or harmful levels of metabolic burden (Hoffmann and Rinas, 2001), from on-line sensor signal combinations correlated to these conditions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein

Warth

Rajkai²,

Mandenius

2010

Journal of Biotechnology

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“…Continuous movements of a point in a principal component diagram (constructed from electronic nose or -tongue measurements) have been used in several other situations, e.g. to identify bacterial infections of a cell culture in a fermenter [24]. A final goal would be to have color indicators, e.g.…”

Section: Resultsmentioning

confidence: 99%

Volatile Emissions from Compressed Tissue

et al. 2013

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Since almost every fifth patient treated in hospital care develops pressure ulcers, early identification of risk is important. A non-invasive method for the elucidation of endogenous biomarkers related to pressure ulcers could be an excellent tool for this purpose. We therefore found it of interest to determine if there is a difference in the emissions of volatiles from compressed and uncompressed tissue. The ultimate goal is to find a non-invasive method to obtain an early warning for the risk of developing pressure ulcers for bed-ridden persons. Chemical analysis of the emissions, collected in compresses, was made with gas-chromatography – mass spectrometry and with a chemical sensor array, the so called electronic nose. It was found that the emissions from healthy and hospitalized persons differed significantly irrespective of the site. Within each group there was a clear difference between the compressed and uncompressed site. Peaks that could be certainly deemed as markers of the compression were, however, not identified. Nonetheless, different compounds connected to the application of local mechanical pressure were found. The results obtained with GC-MS reveal the complexity of VOC composition, thus an array of non-selective chemical sensors seems to be a suitable choice for the analysis of skin emission from compressed tissues; it may represent a practical instrument for bed side diagnostics. Results show that the adopted electronic noses are likely sensitive to the total amount of the emission rather than to its composition. The development of a gas sensor-based device requires then the design of sensor receptors adequate to detect the VOCs bouquet typical of pressure. This preliminary experiment evidences the necessity of studies where each given person is followed for a long time in a ward in order to detect the insurgence of specific VOCs pattern changes signalling the occurrence of ulcers.

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Gas sensor arrays for early detection of infection in mammalian cell culture

Cited by 25 publications

References 8 publications

On-line multi-analyzer monitoring of biomass, glucose and acetate for growth rate control of a Vibrio cholerae fed-batch cultivation

On-line multi-analyzer monitoring of biomass, glucose and acetate for growth rate control of a Vibrio cholerae fed-batch cultivation

Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein

Volatile Emissions from Compressed Tissue

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