Gas‐phase pyrolysis in organic synthesis: New route for synthesis of functionally substituted imidazoles

Abstract

1,2,3‐Triazolylpropanone was prepared and coupled with aryldiazonium salts yielding the corresponding arylhydrazones. Gas‐phase pyrolysis of the hydrazono derivative produced N‐arylamino‐2‐acetylimidazole as well as 2‐acetylimidazole. The latter is the product of further pyrolysis of the former.

Product and Mechanism of Gas-phase Pyrolysis of 2-arylidinehydrazinopyrimidines: Interesting Route to Condensed Heterocycles[1]

“…Gas‐phase pyrolysis provides a useful alternative synthetic strategy for the preparation of novel condensed heterocycles. Many valuable heterocyclic compounds of synthetic importance and potential biological, pharmaceutical, and industrial applications have been prepared using the two major gas‐phase pyrolysis methodologies: static (sealed‐tube) pyrolysis (STP) and flash vacuum pyrolysis (FVP) . Both processes are conducted at low pressure, while FVP is further characterized by relatively short (millisecond) substrate residence time .…”