Gas‐flow assisted ion transfer for mass spectrometry

Garimella, Sandilya; Xu, Wei; Huang, Guangming; Harper, Jason D.; Cooks, R. Graham; Ouyang, Zheng

doi:10.1002/jms.2955

Cited by 48 publications

(60 citation statements)

References 40 publications

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“…20,23,28 In this current study, we observed that the types of the materials used for the ion transfer tube had a significant impact on the ion transfer. For an investigation for selection of the transfer tube, six common types of plastic tubes (all 1 m long, 1.6 mm i.d.)…”

Section: Resultsmentioning

confidence: 69%

Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer

et al. 2015

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A miniature mass spectrometry system with a sampling probe has been developed for real-time analysis of chemicals from sample surfaces. The sampling probe is 1.5m in length and is comprised of one channel for introducing the spray and the other channel for transferring the charged species back to the Mini MS. This system provides a solution to the problem of real-time mass spectrometry analysis of a three-dimensional object in the field and is successful with compounds including those in inks, agrochemicals, explosives, and animal tissues. This system can be implemented in the form of a backpack MS with a sampling probe for forensic analysis or in the form of a compact MS with an intra-surgical probe for tissue analysis.

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Section: Resultsmentioning

confidence: 69%

Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer

et al. 2015

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“…As previously reported, appropriate gas ow can assist the ion transfer. 16,17) en, to facilitate the effective uptake of ions into the original ion inlet of the mass spectrometer, it was necessary to attach a bespoke adaptor to an additional diaphragm pump. is modi cation made it possible for the ion sampling ori ce to be placed immediately next to large living animals, which would otherwise be too large to be placed inside the ionization chamber of a conventional MS system.…”

Section: Introductionmentioning

confidence: 99%

Development of Non-proximate Probe Electrospray Ionization for Real-Time Analysis of Living Animal

et al. 2015

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Ambient ionization mass spectrometry is one of the most challenging analytical tools in the eld of biomedical research. We previously demonstrated that probe electrospray ionization mass spectrometry (PESI-MS) could potentially be used in the rapid diagnosis of cancer. Although this technique does not require a tedious sample pretreatment process, it was not possible for our previously reported setup to be applied to cases involving the direct sampling of tissues from living animal and large animal subjects, because there would not be enough room to accommodate the larger bodies juxtaposed to the ion inlet. To make PESI-MS more applicable for the real-time analysis of living animals, a long auxiliary ion sampling tube has been connected to the ion inlet of the mass spectrometer to allow for the collection of ions and charged droplets from the PESI source (herea er, referred to as non-proximate PESI). Furthermore, an additional ion sampling tube was connected to a small diaphragm pump to increase the uptake rate of air carrying the ions and charged droplets to the ion inlet. is modi cation allows for the extended ion sampling ori ce to be positioned closer to the specimens, even when they are too large to be placed inside the ionization chamber. In this study, we have demonstrated the use of non-proximate PESI-MS for the real-time analysis for biological molecules and pharmacokinetic parameters from living animals.

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“…[40] The flow dynamics in the ion transfer process was also studied. [41] For clinical applications, a rapid evaporative ionization mass spectrometry system (REIMS) system was developed in which tissue was ionized by a surgical knife and the ions subsequently transferred to a mass spectrometer for analysis. [7] A sampling probe using DESI and a narrow (1.6 mm i.d.…”

Section: Introductionmentioning

confidence: 99%

“…[42] Transfer of dry ions generated by atmospheric pressure chemical ionization or by LTP over long distances has been shown to have relatively lower efficiency in comparison with transfer of sprayed ions. [41, 43, 44]…”

Section: Introductionmentioning

confidence: 99%

Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems

Chen

Zhou

et al. 2014

J. Am. Soc. Mass Spectrom.

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Miniature mass spectrometry analytical systems of backpack configuration fitted with sampling probes could potentially be of significant interest for in-field, real-time chemical analysis. In this study, various configurations were explored in which a long narrow tube was used to connect the turbo and backing pumps used to create and maintain vacuum. Also, for the first time we introduced two new types of pumps for miniature mass spectrometers, the Creare 130g drag pump and Creare 350g scroll backing pump. These pumps, along with another Creare 550 turbo pump and the commercially available Pfeiffer HiPace 10 turbo and KnF diaphragm backing pumps, were tested with the backpack configurations. The system performance, especially the scan time, was characterized when used with a discontinuous atmospheric pressure interface (DAPI) for ion introduction. The pumping performance in the pressure region above 1 mtorr is critical for DAPI operation. The 550g turbo pump was shown to have a relatively higher pumping speed above 1 mtorr and gave a scan time of 300 ms, almost half the value obtained with the larger, heavier HiPace 10 often used with miniature mass spectrometers. The 350 g scroll pump was also found to be an improvement over the diaphragm pumps generally used as backing pumps. With a coaxial low temperature plasma ion source, direct analysis of low volatility compounds glass slides was demonstrated, including 1 ng DNP (2,4-Dinitrophenol) and 10ng TNT (2,4,6-trinitrotoluene) with Creare 550g turbo pump as well as 10 ng cocaine and 20 ng DNP with Creare 130g drag pump.

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Gas‐flow assisted ion transfer for mass spectrometry

Cited by 48 publications

References 40 publications

Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer

Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer

Development of Non-proximate Probe Electrospray Ionization for Real-Time Analysis of Living Animal

Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems

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