Gas Exchange in Pregnancy

Metcalfe, James; Bissonnette, John M.

doi:10.1002/cphy.cp030417

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…This was reflected in the rise in heart rate of around 6 bpm in the 1st trimester, with a further 20% increase during the 2nd and 3rd trimesters, for a rise of around 15 bpm by the end of pregnancy 4 , 10 ) . Our study confirms the results of previous studies that pregnancy-induced increases in VE are greater than those typically observed for the metabolic rates of VO 2 and VCO 2 11 ) . Our results differ from those of a previous study with regard to changes in VE/VO 2 and VE/VCO 2 values 12 ) .…”

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confidence: 93%

A Cross-sectional Study of Resting Cardio-respiratory and Metabolic Changes in Pregnant Women

2014

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[Purpose] We examined cardiorespiratory and metabolic changes across the 1st (G1), 2nd (G2) and 3rd (G3) trimesters in pregnant women. [Subjects and Methods] Forty-two healthy, active, non-smoking, pregnant women participated in this study. They were divided into G1, G2 and G3 groups depending on their mean gestational ages at the time of testing which were 10.5 ±2.9, 19.2 ±3.4, and 33.3 ±2.4 weeks of gestation, respectively. Cardio-respiratory and metabolic variables, VO2 (oxygen consumption), VCO2 (carbon dioxide production), and VE (minute ventilation), were measured using indirect calorimetry (IC, gas analyser) to estimate ventilatory equivalents of oxygen (VE/VO2) and carbon dioxide (VE/VCO2), RER (respiratory exchange ratio) and REE (resting energy expenditure). [Results] Women in the late pregnancy period had higher resting VCO2 and RER, whereas the VE/VCO2 ratio was significantly lower than in G1 and in G2. Even though the values of VO2 and REE increased throughout the course of pregnancy, no significant differences were found. [Conclusion] In pregnant women, resting cardiorespiratory and metabolic variables continuously changed throughout the 3 trimesters. Changes in VE/VCO2 and RER indicate shifting metabolic energy substrates. In addition, changes in cardiorespiratory variables, in parallel with gas exchange, indicate a better gas exchange process.

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