“…However, in patients with CHD, there exist large gradients between the PaCO 2 and the end-tidal exhaled alveolar gas carbon-dioxide (P ET CO 2 ). [2,3] In patients with cyanotic CHD, the difference is related to both increases in dead space ventilation and intracardiac venous admixture, whereas in patients with acyanotic CHD, the PAH resulting from the increased pulmonary blood flow may cause a greater ventilation perfusion mismatch resulting in increased PaCO 2 -P ET CO 2 gradients. [4] This difference may be further exaggerated in anesthetized and paralyzed patients with PAH due to atelectasis and increase in dead space ventilation.…”