Gas exchange at a given degree of volume restriction is different in sarcoidosis and idiopathic pulmonary fibrosis

Dunn, Thaddeus L.; Watters, Leslie C.; Hendrix, Clarence; Cherniack, Reuben M.; Schwarz, Marvin I.; Ing, Talmadge E.K

doi:10.1016/s0002-9343(88)80347-4

Cited by 36 publications

(28 citation statements)

References 20 publications

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“…Examples include the identification of a relative elevation of residual volume in hypersensitivity pneumonitis (25) compared with IPF, which is believed to be related to small airway involvement (2). In addition, differences in gas exchange have been confirmed by several groups, with IPF appearing to have a greater reduction in Dl CO despite corrections for lung volume (14,26). In fact, Risk and colleagues noted the greatest increases in P(a-a) O 2 in those patients with UIP compared with desquamative interstitial pneumonia (24).…”

Section: Can Pulmonary Function Testing Aid In Diagnosing Iips?mentioning

confidence: 92%

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Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

Martínez

Flaherty

2006

Proceedings of the American Thoracic Society

137

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Diffuse parenchymal lung diseases are a group of disorders that involve the space between the epithelial and endothelial basement membranes and are generally segregated into four major categories. These include the idiopathic interstitial pneumonias, which are further categorized into seven clinical/radiologic/pathologic subsets. These disorders generally share a common pattern of physiologic abnormality characterized by a restrictive ventilatory defect and reduced diffusing capacity (DL CO ). Pulmonary function testing is often used and recommended in their assessment and management. The potential clinical application of physiologic testing includes to aid in diagnosis, although its value in differential diagnosis is limited. Pulmonary function testing also aids in establishing disease severity and in defining prognosis. In nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis, severely decreased DL CO has proven valuable in this regard. Similarly, exertional desaturation to less than 88% at baseline testing and a decrease in FVC (greater than 10%) over the course of short-term follow-up identify patients at particular risk of mortality. Finally, physiologic testing, especially spirometry and DL CO , have demonstrated value in monitoring response to therapy and identifying disease progression.

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Section: Can Pulmonary Function Testing Aid In Diagnosing Iips?mentioning

confidence: 92%

“…Furthermore, the Dl CO appears to be decreased to a greater extent with IPF than for other DPLDs (14,15). Characteristic arterial blood gas abnormalities in IPF include resting hypoxemia and increased alveolar-arterial oxygen pressure difference (P[a-a] O 2 ] (2).…”

mentioning

confidence: 99%

Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

Martínez

Flaherty

2006

Proceedings of the American Thoracic Society

137

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“…Our data demonstrate the novel finding that plasma uPAR levels are elevated in IPF and correlate with disease severity, using the standard measure of the DLCO. DLCO is also an important prognosticator in IPF patients, opening up the possibility that plasma uPAR might act as a surrogate marker for prognosis in IPF (61)(62)(63)(64)(65).…”

Section: Journal Of Biological Chemistry 12799mentioning

confidence: 99%

Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts

Grove

Southern

Jin

et al. 2014

Journal of Biological Chemistry

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Background:Fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) overexpress the urokinase-type plasminogen activator receptor (uPAR) and are hypermotile. Results: uPAR ligation increases fibroblast motility by localizing ␣5␤1 integrin-Fyn signaling complexes to lipid rafts. Conclusion:The hypermotile phenotype of IPF fibroblasts is due to lipid raft-localized uPAR-integrin-Fyn signaling complexes. Significance: These unique lipid raft signals may be therapeutic targets for IPF.

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“…Dunn et al reported that DLCO of idiopathic pulmonary fibrosis (IPF) patients was significantly lower comparing to sarcoidosis patients; regardless the comparison was performed in patients with the same level of lung volume impairment. This observation suggests that diffusing capacity may not be a sensitive indicator of pulmonary pathology in sarcoidosis since lung volume can be altered independently of abnormalities in the diffusing capacity (Dunn et al, 1988).…”

Section: Diffusion Capacitymentioning

confidence: 95%

Prognostic Factors in Sarcoidosis

Piotrowski¹

2011

Sarcoidosis Diagnosis and Management

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Gas exchange at a given degree of volume restriction is different in sarcoidosis and idiopathic pulmonary fibrosis

Cited by 36 publications

References 20 publications

Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts

Prognostic Factors in Sarcoidosis

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