Gas chromatography-mass spectrometry of maprotiline in serum.

Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN). Many patients suffer side effects and better therapies are necessary. The aim of this study was to evaluate the efficacy of maprotiline (MT) (noradrenergic) compared to AT (mixed noradrenergic and serotonergic) in this disorder. Thirty-five patients entered a randomized, double-blind, crossover trial of these two agents. We found that MT relieved PHN in many patients but was not as effective as AT. Side effects were troublesome with both agents. Relief of steady pain, brief pain and pain on tactile stimulation occurred. Four groups of responses were identified. Some patients reported relief with both agents, some with neither agent and others with only one of the drugs. Most patients were not depressed and analgesia was observed to occur without change in depression ratings in most patients who responded. This result provides evidence that in some patients AT may act via a selective noradrenergic mechanism in relieving PHN and that individuals may differ in the balance and type of neurotransmitters inhibiting pain. Selective noradrenergic agents may be effective if AT fails.

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Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial

Watson

Chipman²,

Reed

et al. 1992

Pain

223

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Determination of maprotiline and desmethylmaprotiline in plasma and urine by gas chromatography with nitrogen—phosphorus detection

Drebit¹,

Baker²,

Dewhurst³

1988

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Gas chromatographic examination of postmortem specimens after maprotiline intoxication

Keller

Zollinger

1997

Forensic Science International

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Gas chromatography-mass spectrometry of maprotiline in serum.

Cited by 3 publications

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Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial

Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial

Determination of maprotiline and desmethylmaprotiline in plasma and urine by gas chromatography with nitrogen—phosphorus detection

Gas chromatographic examination of postmortem specimens after maprotiline intoxication

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