Gas chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb

Khlifi, Aida; Chrifa, Amal Ben; Lamine, Jihen Ben; Thouri, Amira; Adouni, Khawla; Flamini, Guido; Oleszek, Wiesław; Achour, Lotfi

doi:10.1007/s11356-020-08764-7

Cited by 6 publications

(12 citation statements)

References 49 publications

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“…Based on the IC 50 , the C. amblyocarpa EO had a value of 4.52 mg mL −1 compared to 2.11 mg mL −1 of the ascorbic acid as a standard antioxidant. The antioxidant activity of EOs in the present study were lower than those reported from Tunisian ecospecies [ 37 ]. This could be ascribed to the variation in the EO chemical compositions ( Table 1 ).…”

Section: Resultscontrasting

confidence: 96%

“…Carotenoid-derived compounds were determined in a concentration of 3.03%, that represented only two compounds, dihydroedulan II (1.64%) and theaspirane A (1.39%). Only one apocarotenoid-derived compound, hexahydrofarnesyl acetone, was identified with a high relative concentration (7.92%), whereas it was completely absent from the other reported ecospecies of C. amblyocarpa [ 26 , 27 , 28 , 37 ]. Hexahydrofarnesyl acetone is a widely distributed major compound in the EOs of several plants such as Bassia muricata [ 10 ], Heliotropium curassavicum [ 33 ], Hildegardia barteri [ 39 ], Trianthema portulacastrum [ 40 ].…”

Section: Resultsmentioning

confidence: 97%

“…Caryophyllene oxide is a common major compound in several EOs derived from plants such as Cullen plicata [ 34 ], Schinus polygamus [ 35 ], Curcuma sahuynhensis [ 36 ]. Caryophyllene oxide was documented as a minor compound in the EO of Iranian C. amblyocarpa [ 27 ], and totally absent from the EO of C. amblyocarpa collected from the United Arab Emirates [ 26 ], Tunisia [ 37 ], and Saudi Arabia [ 28 ]. On the other hand, trans -caryophyllene (3.45%), and α -muurolene (2.30%) were found to be the main sesquiterpene hydrocarbons, whereas silphiperfol-5,7(14)-diene (0.13%) was determined as a minor component.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, trans -caryophyllene (3.45%), and α -muurolene (2.30%) were found to be the main sesquiterpene hydrocarbons, whereas silphiperfol-5,7(14)-diene (0.13%) was determined as a minor component. trans -caryophyllene has been reported in trace amounts of the EO of the Iranian ecospecies of C. amblyocarpa [ 27 ], whereas it is completely absent from the EO of Saudi [ 28 ], Emirati [ 26 ], and Tunisian [ 37 ] ecospecies.…”

Section: Resultsmentioning

confidence: 99%

“…The oxygenated monoterpenes were represented by 8.72%, which contained seven compounds, with myrtenyl acetate (5.73%) and borneol (1.12%) as major compounds. These two compounds are totally absent from the other ecospecies of C. amblyocarpa [ 26 , 27 , 28 , 37 ]. On the other hand, low diterpene contents were determined and represented by two compounds, geranyl- α -terpinene (0.22%) and phytol (0.17%).…”

Section: Resultsmentioning

confidence: 99%

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Chemical Composition, Allelopathic, Antioxidant, and Anti-Inflammatory Activities of Sesquiterpenes Rich Essential Oil of Cleome amblyocarpa Barratte & Murb.

Abd‐ElGawad

Elgamal

El‐Amier

et al. 2021

Plants

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The integration of green natural chemical resources in agricultural, industrial, and pharmaceutical applications allures researchers and scientistic worldwide. Cleome amblyocarpa has been reported as an important medicinal plant. However, its essential oil (EO) has not been well studied; therefore, the present study aimed to characterize the chemical composition of the C. amblyocarpa, collected from Egypt, and assess the allelopathic, antioxidant, and anti-inflammatory activities of its EO. The EO of C. amblyocarpa was extracted by hydrodistillation and characterized via gas chromatography–mass spectrometry (GC-MS). The chemometric analysis of the EO composition of the present studied ecospecies and the other reported ecospecies was studied. The allelopathic activity of the EO was evaluated against the weed Dactyloctenium aegyptium. Additionally, antioxidant and anti-inflammatory activities were determined. Forty-eight compounds, with a prespondence of sesquiterpenes, were recorded. The major compounds were caryophyllene oxide (36.01%), hexahydrofarnesyl acetone (7.92%), alloaromadendrene epoxide (6.17%), myrtenyl acetate (5.73%), isoshyobunone (4.52%), shyobunol (4.19%), and trans-caryophyllene (3.45%). The chemometric analysis revealed inconsistency in the EO composition among various studied ecospecies, where it could be ascribed to the environmental and climatic conditions. The EO showed substantial allelopathic inhibitory activity against the germination, seedling root, and shoot growth of D. aegyptium, with IC50 values of 54.78, 57.10, and 74.07 mg L−1. Additionally, the EO showed strong antioxidant potentiality based on the IC50 values of 4.52 mg mL−1 compared to 2.11 mg mL−1 of the ascorbic acid as standard. Moreover, this oil showed significant anti-inflammation via the suppression of lipoxygenase (LOX) and cyclooxygenases (COX1, and COX2), along with membrane stabilization. Further study is recommended for analysis of the activity of pure authentic materials of the major compounds either singularly or in combination, as well as for evaluation of their mechanism(s) and modes of action as antioxidants or allelochemicals.

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Section: Resultscontrasting

confidence: 96%