Gas chromatography mass spectrometry couple with quadrupole time-of-flight (GC-QTOF MS) as a powerful tool for profiling of oxygenated sesquiterpenes in agarwood oil

Latib, Erny Haslina Abd; Huq, A.K.M. Moyeenul; Zareen, Seema; Tajuddin, Saıful Nizam

doi:10.1016/j.arabjc.2023.105025

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Overall, the total percentage of sesquiterpenoids was the highest at 77.36%, followed by sesquiterpenes (18.49%) and other compounds (1.41%). This nding is in good agreement with previous studies which found sesquiterpenoids as the major component in AEO 32,33,34 . However, the amount of sesquiterpenoids varied depending on the agarwood species, origin, and extraction methods.…”

Section: Chemical Composition Analysissupporting

confidence: 93%

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chan,

Lakeh,

Wang

et al. 2024

Preprint

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Agarwood essential oil (AEO) has gained attention from healthcare industries due to its numerous pharmacological properties. However, a comprehensive understanding of the chemical composition and its cytotoxic property is lacking. The objective of this study was to investigate the chemical profile as well as the cytotoxic concentration range of AEO derived from Aquilaria sinensis wood. Gas chromatography-mass spectrometry (GC-MS) was employed to identify the AEO components. Results showed that sesquiterpenes and sesquiterpenoids constitute 95.85% of the AEO. Among the major compounds identified are allo-aromadendrene (13.04%), dihydro-eudesmol (8.81%), α-eudesmol (8.48%), bulnesol (7.63%), τ-cadinol (4.95%), dehydrofukinone (3.83%), valerenol (3.54%), cis-nerolidol (2.75%), agarospirol (2.72%), dehydrojinkoh-eremol (2.53%), selina-3,11-dien-9-al (2.36%), guaiol (2.12%) and caryophyllene oxide (2.0%). The presence of volatile quality marker compounds such as 10-epi-ϒ-eudesmol, aromadendrane, β-agarofuran, α-agarofuran, γ-eudesmol, agarospirol and guaiol, indicates that the extracted AEO is of premium grade. Interestingly, the AEO displayed moderate to high toxicity in brine shrimp lethality test (BLST). All studied tumor cell lines (MDA-MB-231, HepG2, B16F10) exhibited varying degrees of sensitivity to AEO, which resulted in time and dose-dependent reduction of cell proliferation. Our findings showed that AEO contains bioactive components that may be exploited in future studies for the development of anti-cancer therapeutics.

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Section: Chemical Composition Analysissupporting

confidence: 93%

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chan,

Lakeh,

Wang

et al. 2024

Preprint

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show abstract

“…Identification in GC-MS involved a comparison of the mass spectrum generated from sample analysis with the National Institute of Standards and Technology (NIST) library, requiring a minimum similarity of ≥80%. GC-FID identification relied on linear retention indices, determined relative to the retention times on a DBI column of a homologous series of C [3] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Datasets of chemical compounds in three different species of aquilaria using GC-MS coupled with GC-FID analysis

Yusoff,

Ismail

2024

Data in Brief

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Gas chromatography mass spectrometry couple with quadrupole time-of-flight (GC-QTOF MS) as a powerful tool for profiling of oxygenated sesquiterpenes in agarwood oil

Cited by 2 publications

References 36 publications

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Datasets of chemical compounds in three different species of aquilaria using GC-MS coupled with GC-FID analysis

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