Gas chromatography-mass spectrometry and high-performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

Wu, Xin; Li, Yubo; Xu, Daoqing; Zhou, Hong; Wang, Jinlei; Guo, Xuejun; Zhang, Yanjun

doi:10.3892/br.2014.382

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…This result may ascribe to the physicochemistry properties of the volatile analytes. It has been reported that these five analytes can be absorbed more efficiently and rapidly because of their fat‐soluble character and smaller molecular weights (<200 Da); they all can easily pass through the buccal mucosa membrane and get into the bloodstream .…”

Section: Resultsmentioning

confidence: 99%

Ultra‐high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb‐pair extract

Wang

Peng

et al. 2016

J of Separation Science

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A fast, sensitive, and reliable ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the simultaneous quantitation and pharmacokinetic study of five phthalides (senkyunolide A, ligustilide, butylidenephthalide, 3-butylphthalide, and levistilide A) in rat plasma after oral administration of Huo Luo Xiao Ling Dan (HLXLD) or Angelica sinensis--Ligusticum chuanxiong herb pair (DG-CX) between normal and arthritis rats. After extraction from blood, the analytes and internal standard were subjected to ultra-high performance liquid chromatography with a Shim-pack XR-ODS column (75 × 3.0 mm(2) , 2.2 μm particles) and mobile phase was composed of methanol and water (containing 0.05% formic acid) under gradient elution conditions, with an electrospray ionization source in the positive ionization and multiple reaction monitoring mode. The lower limits of quantification were 0.192-0.800 ng/mL for all the analytes. Satisfactory linearity, precision, accuracy, mean extraction recovery, and acceptable matrix effect have been achieved. The validated method was successfully applied to a comparative pharmacokinetic study of five bioactive components in rat plasma after oral administration of HLXLD or DG-CX alone, respectively, between normal and arthritic rats. The results showed that there were unlike characters of pharmacokinetics among different groups.

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Section: Resultsmentioning

confidence: 99%

Ultra‐high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb‐pair extract

Wang

Peng

et al. 2016

J of Separation Science

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“…Without the indoor-positioning system, it is hard to find an individual at risk and nearby as soon as possible. For instance, in case an old person has a heart attack, and there is no opportunity to take a su-xiao-jiu-xin pill (this medicine may relieve a sudden heart attack), nearby, people can be informed to near him and help him to take the pill [24]. This will significantly improve the success rate of rescue.…”

Section: Introductionmentioning

confidence: 99%

A Sustainable, Interactive Elderly Healthcare System for Nursing Homes: An Interdisciplinary Design

Yang

Wang

et al. 2022

Sustainability

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Population ageing becomes a perplexing conundrum with social and economic development. Many senior citizens are now empty nesters because the younger generation prefer to stay in metropolises for a better life. Therefore, living in a nursing home is a popular choice for the aged. This objective-oriented paper proposes a sustainable elderly healthcare system for nursing homes. The main work is the design and implementation of a new rapid and interactive assistance service. Based on cost-effective fingerprint indoor-positioning technology, the alert message that a person is at risk will be immediately sent to nearby people before professionals arrive. Warning messages are available when nearing marked areas (e.g., slippery floors). The parallel path-finding algorithm plays a significant role in finding nearby people and alerting people who approach specific areas. Furthermore, this system provides application programming interfaces to connect to health devices, such as smart bracelets, watches, and glasses. In general, the system is designed to ensure the safety of the elderly and improve management efficiency, which corresponds to present smart elderly care proposals from governments.

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“…Moreover, algae may produce compounds that give a disgusting taste and odor to water, as is the case of 2-Methyl-Isoborneol [3], which even at low concentrations can be detected by human senses [4], interfering negatively in water and beverage companies and aquaculture [5][6][7][8]. Isoborneol, a compound with a chemical structure similar to 2-methyl-Isoborneol, can be found in vegetable oils and is used in applications ranging from antiviral for herpes [9], in the treatment treatment of cardiovascular diseases [10], and as a natural repellent [11]. Therefore, the presence of these compounds in drinking water must be monitored and controlled by highly sensitive and easy handling instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Tuning the Electrical Properties of Electrospun Nanofibers with Hybrid Nanomaterials for Detecting Isoborneol in Water Using an Electronic Tongue

et al. 2019

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The presence of contaminants in water is a subject of paramount importance nowadays, which can make water improper to human consumption even when these contaminants are present at very low concentrations, causing health issues and economic losses. In this work, we evaluated the performance of nanocomposites based on nylon 6,6/chitosan electrospun nanofibers modified by cellulose nanowhiskers combined with functional materials like silver nanoparticles, gold nanoparticles, and reduced graphene oxide to be used as sensing layers of an electronic tongue (e-tongue) to detect Isoborneol. This compound, found in some plants and essential oils, is used as a natural repellent and also to produce many other chemicals. Additionally, its chemical structure is related to that of 2-methylisoborneol, a critical pollutant in aqueous media. The synergism between the nanomaterials combined with electrospun nanofibers could be verified by the enhancement of the charge transference ability. Additionally, electrical capacitance data measured with the impedimetric e-tongue were treated by Principal Component Analysis (PCA), and revealed the sensing system was able to discriminate samples contaminated with Isoborneol at nanomolar concentrations. Moreover, the electronic tongue system could detect Isoborneol in real water samples under different concentrations.

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Gas chromatography-mass spectrometry and high-performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

Cited by 9 publications

References 13 publications

Ultra‐high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb‐pair extract

Ultra‐high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb‐pair extract

A Sustainable, Interactive Elderly Healthcare System for Nursing Homes: An Interdisciplinary Design

Tuning the Electrical Properties of Electrospun Nanofibers with Hybrid Nanomaterials for Detecting Isoborneol in Water Using an Electronic Tongue

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