Gas chromatographic method for the determination of vincamine in blood

Kinsun, H.; Moulin, Maryline

doi:10.1016/0021-9673(77)80015-0

Cited by 15 publications

(5 citation statements)

References 2 publications

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“…The achieved LOD revealed the high sensitivity of the described SW-AdAS voltammetric method over most of the previously reported ones for determination of vincamine; (10 ng ml Ϫ1 ), 8,15) (5 ng ml Ϫ1 ), 13,14,16) (3 ng ml Ϫ1 ), 9) (0.25 mg ml Ϫ1 ) 10) and (0.05 mg ml Ϫ1 ).…”

mentioning

confidence: 66%

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Development and Validation of an Adsorptive Stripping Voltammetric Method for the Quantification of Vincamine in Its Formulations and Human Serum Using a Nujol-Based Carbon Paste Electrode

Beltagi

2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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mentioning

confidence: 66%

“…Vinca extracts, pharmaceutical formulations, plasma and urine). These methods include spectrophotometry, [5][6][7] titrimetry, 6) selected ion monitoring, 7) gas chromatography (GC) 9,10) and liquid chromatography (LC).…”

mentioning

confidence: 99%

Development and Validation of an Adsorptive Stripping Voltammetric Method for the Quantification of Vincamine in Its Formulations and Human Serum Using a Nujol-Based Carbon Paste Electrode

Beltagi

2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…GC separation has been done on underivatized vincamine [15,16]. In the present study, a GC program was devised for the underivatized compound to allow approximately 85% of vincamine to survive the injection and column conditions.…”

Section: Derivatization Of Vincamine and Limitsof Detectionmentioning

confidence: 99%

“…Thin-layer chromatography (TLC) combined with UV reflectance spectroscopy [11] and countercurrent chromatography with thermospray mass spectrometry [12] are other techniques that also have been used to analyze vincamine. Gas chromatography (GC) analysis has been performed on both derivatized [13,14] and nonderivatized forms of vincamine [15,16] with flame ionization detector (FlO) [13], nitrogen flame ionization detector (NFID) [15,16], or selected ion electron ionization mass spectrometric detectors [14]. The electron ionization (EO mass spectrum of vincamine has been studied in great detail [13,[17][18][19].…”

mentioning

confidence: 99%

Ion-molecule reactions of oxygenated chemical ionization reagents with vincamine

Bauerle

Hall

Tran

et al. 1996

J. Am. Soc. Mass Spectrom.

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The ion-molecule reactions of ions from acetone, dimethyl ether, 2-methoxyethanol, and vinyl methyl ether with vincamine were investigated. Reactions with dimethyl ether result in [M+13](+) and [M+45](+) products, reactions with 2-methoxyethanol produce [M+13](+) and [M+89](+) ions, and reactions with acetone or vinyl methyl ether ions generate predominantly [M+43](+) ions. Collision-activated dissociation and deuterium labeling experiments allowed speculation about the product structures and mechanisms of dissociation. The methylene substitution process was shown to occur at the hydroxyl oxygen and the phenyl ring of vincamine for dimethyl ether reactions, but the methylene substitution process was not favored at the hydroxyl oxygen for the 2-methoxyethanol reactions, instead favored at the 12 phenyl position. The reaction site is likely different for the 2-methoxyethanol ion due to its capability for secondary hydrogen-bonding interactions. For the [M+45](+) and [M+89](+) ions, evidence suggests that charge-remote fragmentation processes occur from these products. In general, the use of dimethyl ether ions or 2-methoxyethanol ions for ionmolecule reactions prove highly diagnostic for the characterization of vincamine; both molecular weight and structural information are obtained. Limits of detection for vincamine with dimethyl ether chemical ionization via this technique on a benchtop ion trap gas chromatography-tandem mass spectrometer are in the upper parts per trillion range.

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“…Although modern cell culture techniques such as those involving root and hairy root cultures afford relatively high alkaloid levels in appropriate production organisms, a higher detector sensitivity is always desirable. However, steady development work on NPD has yielded an efficient device for many analytical applicatons involving alkaloids (Vitzhum et al, 1974;Kinsun and Moulin, 1977;Severson et al, 1981;Turner et a[., 1981;Kim 1986). In the present investigation, application of a GC-NPD detector/PTV injector assembly has been compared with that of more conventional instrumentation in the analysis of some tropane alkaloids.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen‐phosphorus detector potential in tropane alkaloid gas chromatography

Martinsen

Hiltunen

Huhtikangas

1992

Phytochemical Analysis

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A gas chromatographic (GC) nitrogen‐phosphorus detector (NPD) is compared with a flame ionization detector (FID) for the quantitation of some important tropane alkaloids present in plant material. Though slightly cumbersome in routine work, NPD has a distinct sensitivity advantage over FID for these alkaloids. An injector of the programmed temperature vaporizer (PTV) type permitted extension of the range of solvents which may be employed for the preparation of alkaloid samples for GC assays in which detection is to be accomplished by NPD.

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Gas chromatographic method for the determination of vincamine in blood

Cited by 15 publications

References 2 publications

Development and Validation of an Adsorptive Stripping Voltammetric Method for the Quantification of Vincamine in Its Formulations and Human Serum Using a Nujol-Based Carbon Paste Electrode

Development and Validation of an Adsorptive Stripping Voltammetric Method for the Quantification of Vincamine in Its Formulations and Human Serum Using a Nujol-Based Carbon Paste Electrode

Ion-molecule reactions of oxygenated chemical ionization reagents with vincamine

Nitrogen‐phosphorus detector potential in tropane alkaloid gas chromatography

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