Gas chromatographic determination of zopiclone in plasma after solid-phase extraction

Development of two charge transfer complex spectrophotometric methods for determination of tofisopam in tablet dosage form

“…Spectrophotometry [5,6], spectrofluorometry [5,7], high performance liquid chromatography (HPLC) using either reverse-phase chromatography [8][9][10], enantiomeric separation [11,12], gas chromatography (GC) [13,14], and super critical chromatography [15] have been cited in the literature for determination of tofisopam in its dosage form. Although, most of these methods are sensitive, however, their disadvantages include long run times, derivatization procedure and high cost.…”

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

“…Buspirone hydrochloride -8-[4-(4-Pyrimidin-2-ylpiperazin-l-yl)butyl]-8-azaspiro [4,5]decane-7,9-dione hydrochloride CAS-33386-08-2 -is an azaspirodecanedione (BusCl). 1 Buspirone hydrochloride has dopaminergic, noradrenergic, and serotonin-modulating properties and its anxiolytic effects appear to be related to its action on serotonin (5-hydroxytryptamine; 5-HT) neurotransmission.…”

“…Buspirone has been shown to be as effective as benzodiazepine in the short-treatment of generalized anxiety disorders and to be less likely to cause sedation or psychomotor and cognitive impairment. It has been determined using a different number of techniques including spectrophotometry, 2 GC, 3,4 capillary zone electrophoresis, 5 voltammetry, 6 HPLC, 7,8 TLC, 9 LC, 10 LC-MS, 11,12 capillary gas chromatography, 13 colorimeric, 14 GC-MS 15 and differential pulse polarography. 16 Although there is an increasing demand for chemical surveillance in the environmental, medical and many other industries, which has created the need for highly sensitive, selective, precise and inexpensive techniques, no ion-selective electrode (ISE) has been constructed for the determination of Buspirone.…”

Zopiclone degradation in biological samples : Characteristics and consequences in forensic toxicology

“…Several analytical methods, including high performance liquid chromatography (HPLC), gas chromatography (GC), gas chromatography mass spectrometry (GC-MS), liquid chromatography mass spectrometry (LC-MS) and liquid chromatography tandem mass spectrometry (LC-MS/MS), have been developed for the identification and quantification of ZOP in whole blood, serum and/or plasma [118,[120][121][122][123][124][125][126][127][128][129][130][131][132][133][134][135][136]. Some assays (HPLC, LC-MS, LC-MS/MS) have also been developed to separate and determine ZOP [127,[137][138][139] and/or its metabolites (NDZOP and ZOPNO) in urine [140][141][142].…”