Gas chromatographic analysis of trace gas impurities in tungsten hexafluoride

Laurens, Johannes B.; Coning, Piet de; Swinley, John

doi:10.1016/s0021-9673(00)01253-x

Cited by 17 publications

(4 citation statements)

References 7 publications

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“…The PDHID is one of the most sensitive universal detectors for GC (Lauren et al 2001) and it has been pointed out that the sensitivity of the PDHID exceeds the sensitivity of the thermal conductivity detector (TCD) and flame ionization detector (FID) by 500-and 50-fold, respectively (Forsyth andTaylor 2002, Roberge et al 2004). The dose-response profiles for the four Mycobacterial volatiles are shown in figure 4.…”

Section: Sensitivity and Linear Dynamic Rangementioning

confidence: 99%

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

et al. 2013

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Pathogenic Mycobacteria cause diseases in animals and humans with significant economic and societal consequences. Current methods for Mycobacterial detection relies upon time- and labor-intensive techniques such as culturing or DNA analysis. Using gas chromatography and mass spectrometry, four volatile compounds (methyl phenylacetate, methyl p-anisate, methyl nicotinate and o-phenyl anisole) were recently proposed as potential biomarkers for Mycobacteria. We demonstrate for the first time the capabilities of a field-deployable, pulsed discharge helium ionization detector (PDHID) for sensing these volatiles. We determined the analytical performance of the PDHID toward these Mycobacterial volatiles. Detector performance was moderately affected over the temperature range of 150 to 350 °C. The linear dynamic range for all four analytes exceeded three orders of magnitude. The limits of detection (LOD) and quantitation (LOQ) were calculated as 150 and 450 pg respectively, for all compounds, except methyl phenylacetate (LOD and LOQ, 90 and 270 pg, respectively). Control charts revealed that the PDHID detection system was generally stable, and deviations could be traced to common causes and excluded special causes. Grob tests and ionization potential data suggest that the PDHID is capable of detecting Mycobacterial volatiles in a complex milieu such as culture headspace or breath samples from tuberculosis patients. The diagnostic potential of the PDHID is critical to our goal of a handheld, field-deployable 'sniffer' system for biological pathogens and chemical warfare agents.

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Section: Sensitivity and Linear Dynamic Rangementioning

confidence: 99%

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

et al. 2013

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“…Impurities in tungsten hexafluoride (H 2 , O 2 , N 2 , CO, CO 2 and SF 6 ) have been measured by He-PDPID [35]. A backflush-to-vent valve switching technique separated the impurities from the matrix which was too corrosive to allow contact with the analytical column and detector.…”

Section: Inorganicsmentioning

confidence: 99%

Pulsed discharge detector: theory and applications

Forsyth¹

2004

Journal of Chromatography A

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The pulsed discharge detector (PDD) is a significant advancement in gas chromatography (GC) detector design which can be operated in three different modes: pulsed discharge helium ionization (He-PDPID), pulsed discharge electron capture (PDECD) and helium ionization emission (PDED). The He-PDPID can detect permanent gases, volatile inorganics and other compounds which give little or no response with the flame ionization detector (FID) and has significantly better limits of detection (minimum detectable quantities (MDQs) in low picogram range) than can be achieved with a thermal conductivity detector (typically not lower than 1 ng). The PDECD has similar or better sensitivity (MDQs of 10(-15) to 10(-12) g) than radioactive source ECD but does not require licensing, wipe tests and other administrative or safety requirements which have increased over security concerns. The PDED shows promise as an extremely selective and sensitive elemental detector but a commercial unit is not presently available. In this report, the theory of operation, applications of the PDD and the practical aspects of using this novel detector are presented.

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“…6,7 For the determination of inorganic gases, a thermal conductivity detector (TCD) is widely used; however, it is not suitable for the sensitive determinations, because the TCD is not able to detect concentrations below a few hundred ppm. In the GC method, a methanation reaction by a methanizer has usually been used for sensitive determinations of CO and CO2 before flame ionization detection (FID).…”

Section: Introductionmentioning

confidence: 99%

Rapid Temperature-Programmed Separation of Carbon Monoxide and Carbon Dioxide on a Packed Capillary Column in Gas Chromatography: Application to the Evaluation of Photocatalytic Activity of TiO2

et al. 2013

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Carbon monoxide (CO) and carbon dioxide (CO2) were determined in a conventional capillary gas chromatography-flame ionization detector (GC-FID) by introducing a packed-capillary column and a methanizer. Due to good compatibility with rapid temperature-programmed operation of the packed capillary column, several volatile compounds, including CO and CO2, were rapidly eluted along with satisfactory resolution and sample loading capacity. The limit of quantifications of CO and CO2 were 5 and 3 ppm, respectively, with an injection volume of 0.5 mL. The developed system was then successfully applied to evaluating the photocatalytic decomposition of volatile organic compounds on titanium dioxide (TiO2).

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Gas chromatographic analysis of trace gas impurities in tungsten hexafluoride

Cited by 17 publications

References 7 publications

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

Pulsed discharge detector: theory and applications

Rapid Temperature-Programmed Separation of Carbon Monoxide and Carbon Dioxide on a Packed Capillary Column in Gas Chromatography: Application to the Evaluation of Photocatalytic Activity of TiO2

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