Garlic supplement lowers blood pressure in 40-60 years old hypertensive individuals, regulates oxidative stress, plasma cholesterol and protrombin index

Abstract

Background: Arterial hypertension is associated with tissue remodeling, oxidative stress and decreased production of such vasorelaxants as nitric oxide (NO) and hydrogen sulfi de (H 2 S). Garlic shows promises in treatment of hypertension and could be used as an antioxidative agent and a source/precursor of H 2 S for decreasing of blood vessel stiffness. Objective:The aim was to study the effectiveness of garlic supplement in the treatment of grade II hypertension in male patients. Methods:The study was carried out in Kozyatyn Central District Hospital (Kozyatyn, Vinnytsia region, Ukraine). Patients with grade II hypertension (40-60 years old men) and healthy individuals of the same age and gender were included into study (n = 10 in each group). Garlic supplement (400mg per day) was included to the treatment after 10 day of standard antihypertensive therapy (angiotensin converting enzyme inhibitors, beta blockers). Echocardiography, biochemical control of blood, determination of plasma H 2 S level and markers of oxidative-nitrozative stress were performed during study period.Results: It was found that 30 days of garlic supplement on the background of a standard antihypertensive therapy reduced both systolic and diastolic blood pressure by 16.5 and 12.5 mmHg respectively (P<0,01 for both). The plasma H 2 S level was signifi cantly increased after 30 days of treatment. There was a positive effect of garlic supplement consumption on blood vessels in the form of a decrease in total peripheral vascular resistance by 10% (P<0,01). The production of reactive oxygen species and malonic dialdehyde was signifi cantly reduced in blood plasma indicating antioxidative effect of garlic. Importantly, activity of constitutive NO synthase was restored and inducible NO synthase activity was inhibited. There was a decrease in plasma cholesterol by 30% and prothrombin index (P<0,001 for both). No signifi cant changes in urea, creatinine, glucose, and erythrocyte counts were observed. Conclusion:The results of our study indicate the effectiveness of garlic supplement consumption as a hypotensive, cholesterol-lowering and mild antithrombotic agent in the treatment of hypertension in elderly patients. Garlic supplement consumption likely improves H 2 S and NO synthesis in hypertensive patients.

Efek Black Garlic Bawang Lanang terhadap Ankle Brachial Index pada Pasien Hipertensi: Penelitian Kuasi Eksperimen

“…Hasil penelitian dari model invitro pada hewan coba juga memperlihatkan efektivitas pemberian black garlic pada penurunan kolesterol dan low density lipoprotein (Prihanti et al, 2019). Selain itu, Olexandr M et al (2021) menyatakan bagwa dengan pemberian black garlic, produksi spesies oksigen reaktif dan dialdehid malonik berkurang secara signifikan dalam plasma darah yang menunjukkan efek antioksidan bawang putih, dan aktivitas sintase NO konstitutif dipulihkan dan aktivitas sintase NO yang diinduksi dihambat.…”