Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes

Pedraza‐Chaverrí, José; Maldonado, Perla D.; Medina-Campos, Omar Noel; Olivares-Corichi, Ivonne María; Granados-Silvestre, Marı́a de los Ángeles; Hernández-Pando, Rogelio; Ibarra-Rubio, María Elena

doi:10.1016/s0891-5849(00)00354-3

Cited by 189 publications

(129 citation statements)

References 48 publications

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“…These results are in good agreement with those previously reported [24,3] . Our results also showed that treatment with different doses of C. pareira reduced the levels of urinary glucose, serum urea, serum creatinine and lipid peoxidation in kidneys whereas increases the urinary creatinine and glutathione levels in kidneys, dose dependently.…”

Section: Discussionsupporting

confidence: 94%

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Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Reddy¹,

Kumar²,

Swamy³

et al. 2014

Phcog J.

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Objective: To evaluate the potential nephroprotective and antioxidant activity of hydroalcoholic Cissampelos pareira (C. pareira) whole plant extract using gentamicin-induced rats. Methods: For studying acute toxicity study, single oral dose of 2g/kg hydroalcoholic extract of C. pareira was evaluated in rats by oral gavage. The nephroprotective activity was evaluated using gentamicin-induced model in rats. In-vitro antioxidant activity was evaluated by using DPPH assay and reducing power assay. In-vivo antioxidant activity was evaluated by using glutathione and lipid peroxidation estimations in gentamicin-induced rats. Hydroalcoholic C. pareira whole plant extract was given at a dose of 200 and 400 mg/kg p.o. Results: For acute toxicity testing rats administered with the extract at a dose 2 g/ kg. the result showed no toxicity. Hydroalcoholic C. Pareira whole plant extract (200 and 400 mg/kg p.o) significantly decrease the elevated urinary glucose levels in the urine, decrease the elevated urea and creatinine levels in blood and increase the urinary creatinine levels in gentamicin-induced nephrotoxic rats. The extract had shown significant dose dependent increase in the DPPH and reducing power activity. There were a dose dependent decreasing and increasing of lipid peroxidation, glutathione levels in hydoalcoholic extract treated groups respectively. Conclusion: This study exhibits that hydroalcoholic C. pareira whole plant extract poses nephroprotective activity which may be due to its antioxidant activity.

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Section: Discussionsupporting

confidence: 94%

“…Antioxidants have been shown to improve signs of gentamicin induced nephrotoxicity [3] . A potential therapeutic approach to defend or reverse gentamicin induced oxidative damage and nephrotoxicity could have more importance for clinical consequences [4] .…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Reddy¹,

Kumar²,

Swamy³

et al. 2014

Phcog J.

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“…It was demonstrated that, between the group provided with a garlic diet and the control group, there were no significant differences in the plasma glutathione peroxidase enzyme activities, as well as the kidney superoxide dismutase, glutathione peroxidase and kidney catalase enzyme activities (7). In another study, Maldonado et al have investigated the antioxidant effects of garlic in experimental animal models by inducing nephrotoxicity with gentamicin.…”

Section: Discussionmentioning

confidence: 99%

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods: Twenty four healthy male Wistar rats, weighing between 220 -260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group (Group I, n = 8), gentamicin injection with garlic supplementation group (Group II, n = 8), and control group (Group III, n = 8). Urine from the rats was collected and the volume (mLand pH values were measured. Then urea (mg/dL), creatinine (mg/dL), total protein (g/dL) and cystatin (mg/L) values were measured for the blood samples obtained from tail veins. Results:The median NAG value for the control group (52.050 U/L) was similar to value for Group II (56.400 U/L), which received gentamicin and the garlic diet. However, the median NAG value for Group I (77.030 U/L), which received gentamicin without garlic supplementation, was determined to be statistically significantly higher (p = 0.010) than the value for the control group. In addition, the mean cystatin value for Group II (1.360 U/L) was found to be statistically significantly lower than the value for the Group I (2.240 U/L) (p = 0.015).Conclusions: In this study we showed the effect of 4% pulverized garlic supplemented diet for preventing nephrotoxicity induced by gentamicin in rats by using as parameters NAG in urine samples and cystatin C in serum samples.

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“…[36][37][38] Since ROS have been implicated in mediating various pathological processes (e.g., ischemic heart disease, peripheral arterial occlusive disease, hypertension, hyperlipidemia, and toxicities), it can be suggested that the beneficial effects of garlic in these conditions may be due to its antioxidant activity. [39][40][41][42][43][44][45][46] The compounds in garlic (S-allylcysteine, S-allyl-mercapto cysteine, S-allyl-cysteine sulfoxide, and allicin), through their radical scavenging abilities, have been suggested to be responsible for its preventive effects against oxidative injury. 14 Diallyldisulfide (DADS), a metabolite of allicin, includes redoxactive sulfhydryl (SH)-or disulfide (-S-S)-groups which have already been proven to act as radical scavengers.…”

Section: Discussionmentioning

confidence: 99%

Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

et al. 2011

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Chronic renal failure (CRF) is associated with oxidative stress that promotes production of reactive oxygen species and cytokine release. We aimed to investigate the possible protective and antioxidant effects of aqueous garlic extract (AGE) in a rat model of CRF. Male Sprague-Dawley rats were randomly assigned as either CRF group with 5/6 reduction in the renal mass or sham-operated control group. CRF group received either saline or AGE (250 mg/kg/day/1 mL) orally for 3 weeks. At the end of the 3 weeks, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen (BUN) and lactate dehydrogenase (LDH) activity, and TNF-α and IL-1β levels were measured in the serum samples, while malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase (MPO) activity were determined in the kidney, lung, and heart samples. CRF caused significant decreases in tissue GSH, which were accompanied with significant increases in MDA levels and MPO activities, while the circulating levels of the LDH activity, creatinine, BUN, TNF-α, and IL-1β were elevated. AGE treatment alleviated CRF-induced oxidative changes in the injured tissues, while CRF-induced elevations in the blood levels of the pro-inflammatory cytokines and LDH were reduced. In conclusion, CRF-induced oxidative tissue injury occurs via the activation of pro-inflammatory mediators and by neutrophil infiltration into tissues and that the protective effects of garlic on CRF-induced injury can be attributed to its ability to inhibit neutrophil infiltration and pro-inflammatory mediators. These findings suggest that garlic, as a supplementary to diet, may have a potential therapeutic use in delimitating the systemic oxidant effects of CRF on remote organs.

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Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes

Cited by 189 publications

References 48 publications

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

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