Gardeniae Fructus Extract Alleviates Dexamethasone-Induced Muscle Atrophy in Mice

Lee, Jin A; Lee, Se Hui; Shin, Mi‐Rae; Park, Hae-Jin; Roh, Seong‐Soo

doi:10.1089/jmf.2022.k.0038

Cited by 2 publications

(1 citation statement)

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“…Muscle contains the largest storage of protein in the body and is one of the most important tissues. It plays various roles, including respiration, locomotion, and glucose homeostasis [ 1 ]. Muscle atrophy caused by various circumstances such as aging can lead to diseases such as myopathy and muscular dystrophy and various complications such as diabetes, heart failure, and cancer [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Whey Peptide Alleviates Muscle Atrophy by Strongly Regulating Myocyte Differentiation in Mice

Lee,

Shin,

Kim

et al. 2024

Medicina

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Background and Objectives: Muscle atrophy occurs when protein degradation exceeds protein synthesis, resulting in imbalanced protein homeostasis, compromised muscle contraction, and a reduction in muscle mass. The incidence of muscle atrophy is increasingly recognized as a significant worldwide public health problem. The aim of the current study was to evaluate the effect of whey peptide (WP) on muscle atrophy induced by dexamethasone (DEX) in mice. Materials and Methods: C57BL/6 mice were divided into six groups, each consisting of nine individuals. WPs were orally administered to C57BL/6 mice for 6 weeks. DEX was administered for 5–6 weeks to induce muscle atrophy (intraperitoneal injection, i.p.). Results: Microcomputer tomography (CT) analysis confirmed that WP significantly increased calf muscle volume and surface area in mice with DEX-induced muscle atrophy, as evidenced by tissue staining. Furthermore, it increased the area of muscle fibers and facilitated greater collagen deposition. Moreover, WP significantly decreased the levels of serum biomarkers associated with muscle damage, kidney function, and inflammatory cytokines. WP increased p-mTOR and p-p70S6K levels through the IGF-1/PI3K/Akt pathway, while concurrently decreasing protein catabolism via the FOXO pathway. Furthermore, the expression of proteins associated with myocyte differentiation increased noticeably. Conclusions: These results confirm that WP reduces muscle atrophy by regulating muscle protein homeostasis. Additionally, it is believed that it helps to relieve muscle atrophy by regulating the expression of myocyte differentiation factors. Therefore, we propose that WP plays a significant role in preventing and treating muscle wasting by functioning as a supplement to counteract muscle atrophy.

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Section: Introductionmentioning

confidence: 99%