Garcinol: Preclinical Perspective Underpinning Chemo- and Radiosensitization of Cancer

Banerjee, Sanjeev; Parasramka, Mansi; Paruthy, Shivani B.

doi:10.1016/b978-0-12-812373-7.00015-2

Cited by 11 publications

(9 citation statements)

References 88 publications

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“…The new molecule should also have a favourable pharmacokinetic data and should be non-toxic. Although, currently there is no data which robustly confirm the bioavailability of garcinol, preliminary animal studies indicate that garcinol is well absorbed after oral/intraperitoneal administration and can readily cross the cell membrane to reach the interiors of mammalian cells [33]. Moreover, earlier studies have indicated that garcinol does not show apparent toxicity in animals [34].…”

Section: Introductionmentioning

confidence: 99%

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis

Warriar

Barve

Prabhakar

2019

IAD

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Background: Garcinia indica also known as kokum is used in traditional system of medicine for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant and anti-cancer activity. Apart from these, few patents claim that garcinol also has anti-obesity and hepatoprotec-tive effect and has a potential to be used for the treatment of renal disorders, endometriosis and cardiac dysfunction.Objective:Garcinol Enriched Fraction (GEF) from the fruit rind of Garcinia indica should be effective in the treatment of arthritis, one of the chronic inflammatory disorder owing to its anti-inflammatory property as indicated by earlier experiments.Methods:GEF was prepared from the fruit rind of Garcinia indica and quantified using LC-MS/MS. It was found to contain 89.4% w/w of garcinol. GEF was evaluated at the dose of 10mg/kg for its efficacy against Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar albino rats. Paw volumes of both sides were measured by Plethysmometer and body weight was recorded on 0, 1, 5, 12 and 21st day. The hyperalgesic response was also measured by motility test and stair climbing test.Results:GEF showed a significant reduction in paw swelling (p < 0.0001) and arthritis index (p < 0.0001) exhibiting anti-inflammatory potential. It also improves the motility and stair climbing ability of experimental animals (p < 0.05), thus reducing hyperalgesia.Conclusion:Garcinol enriched fraction shows anti-arthritic activity in experimental animals.

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Section: Introductionmentioning

confidence: 99%

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis

Warriar

Barve

Prabhakar

2019

IAD

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“…The main types of leukemia are acute myeloid (AML), chronic myeloid (CML), acute lymphocytic (ALL), and chronic lymphocytic (CLL). It also comprises myeloma and two types of lymphoma: Hodgkin’s and non-Hodgkin’s (NHL) ( 159 ). Hematologic malignancies have reduced the quality of life, especially in developing and emerging countries ( 160 ).…”

Section: The Antineoplastic Roles Of Amps In Various Cancer Typesmentioning

confidence: 99%

Clinical Applications and Anticancer Effects of Antimicrobial Peptides: From Bench to Bedside

et al. 2022

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Cancer is a multifaceted global health issue and one of the leading causes of death worldwide. In recent years, medical science has achieved great advances in the diagnosis and treatment of cancer. Despite the numerous advantages of conventional cancer therapies, there are major drawbacks including severe side effects, toxicities, and drug resistance. Therefore, the urgency of developing new drugs with low cytotoxicity and treatment resistance is increasing. Antimicrobial peptides (AMPs) have attracted attention as a novel therapeutic strategy for the treatment of various cancers, targeting tumor cells with less toxicity to normal tissues. In this review, we present the structure, biological function, and underlying mechanisms of AMPs. The recent experimental studies and clinical trials on anticancer peptides in different cancer types as well as the challenges of their clinical application have also been discussed.

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“…Participants (1) aged 8 to 18 years old, (2) diagnosed with haematological malignancy, (3) undergoing chemotherapy, (4) able to communicate in Amharic, and (5) with written parental consent and oral child assent will be recruited. Participants (1) with evidence of developmental, psychological and/or psychiatric illness or problems, (2) unable to collaborate in the study due to acute illness, and/or (3) having hearing or speech problems that could affect the study process will be excluded.…”

Section: Participantsmentioning

confidence: 99%

“…Haematological malignancies include malignancies of the blood, bone marrow, and lymph nodes. Leukaemia, lymphoma, and myeloma are the most common types of paediatric cancer all over the world [ 1 – 3 ]. In Ethiopia, evidence shows that more than 50% of childhood cancers are haematological malignancies [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a culturally tailored cognitive-behavioural intervention for Ethiopian children with haematological malignancies: study protocol for randomised controlled trial

Melesse

Chau

2022

Trials

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Background Paediatric cancer patients often experience anxiety and depression. Evidence suggests that cognitive-behavioural interventions may help reduce anxiety and depression in children undergoing cancer treatment. However, only a few studies evaluated its impact on the psychological well-being and quality of life of paediatric cancer patients globally. In Ethiopia, there has been no published study to date. Thus, this trial aims to evaluate the efficacy of a culturally tailored cognitive-behavioural intervention for Ethiopian children with haematological malignancies receiving chemotherapy. Methods A single-blinded, parallel-group, two-arm, repeated measure randomised controlled trial will be conducted. Eighty children aged 8 − 18 years with haematological malignancy receiving chemotherapy will be recruited and randomly assigned to experimental or control groups. The experimental group will receive five sessions of introducing cognitive-behavioural intervention, identifying and modifying maladaptive thoughts and behaviour, behavioural activation, practising deep breathing exercises, reassessing goals or treatment plans, and encouraging participants to maintain changes. Each session will be conducted face-to-face for 30–35 min a week. The control group will receive usual care. The outcomes will be measured at baseline, post-intervention, and one month after the intervention using the Revised Child Anxiety and Depression Scale and Paediatric Quality of Life Inventory Generic Core Score 4.0. Discussion The findings of this study will provide evidence to support the integration of culturally effective cognitive-behavioural intervention strategies into paediatric oncology practice and thus, add new knowledge to the literature and help improve the care of children with haematological malignancies receiving chemotherapy. If the cognitive-behavioural intervention is shown to be effective and culturally acceptable, it will provide evidence to include the intervention as a standard of care in paediatric haematology/oncology. Trial registration ClinicalTrials.gov NCT05270655. Registered on March 8, 2022.

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Garcinol: Preclinical Perspective Underpinning Chemo- and Radiosensitization of Cancer

Cited by 11 publications

References 88 publications

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis

Clinical Applications and Anticancer Effects of Antimicrobial Peptides: From Bench to Bedside

Efficacy of a culturally tailored cognitive-behavioural intervention for Ethiopian children with haematological malignancies: study protocol for randomised controlled trial

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