Garcinol, a multifaceted sword for the treatment of Parkinson's disease

Deb, Satarupa; Phukan, Banashree Chetia; Mazumder, Muhammed Khairujjaman; Dutta, Ankumoni; Paul, Rajib; Bhattacharya, Pallab; Sandhir, Rajat; Borah, Anupom

doi:10.1016/j.neuint.2019.04.004

Cited by 33 publications

(18 citation statements)

References 91 publications

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“…Only ~10% of PD cases show family history; while the remaining 90% of PD have no clearly defined genetic cause [168]. The pathogenesis of PD is linked with progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) area of the brain and the intracellular deposition of misfolded α-synuclein (Table 1) [66,67].…”

Section: Inflammaging In Neurodegenerative Diseasesmentioning

confidence: 99%

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo

Stetskiv

et al. 2019

IJMS

336

201

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It has been proposed that a chronic state of inflammation correlated with aging known as inflammaging, is implicated in multiple disease states commonly observed in the elderly population. Inflammaging is associated with over-abundance of reactive oxygen species in the cell, which can lead to oxidation and damage of cellular components, increased inflammation, and activation of cell death pathways. This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis. Recently published mechanistic details of the roles of reactive oxygen species in inflammaging and various diseases will also be discussed. Advancements in potential treatments to ameliorate inflammaging, oxidative stress, and consequently, reduce the morbidity of multiple disease states will be explored.

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Section: Inflammaging In Neurodegenerative Diseasesmentioning

confidence: 99%

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo

Stetskiv

et al. 2019

IJMS

336

201

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“…Several studies have reported protective role of phytochemicals, including curcumin, tea polyphenols, caffeine, resveratrol, etc. in ameliorating OS in animal models of toxin-induced parkinsonism (Fujisawa et al, 2004; Guo et al, 2007; Yu et al, 2010; Kachroo et al, 2010; Deb et al, 2019; see Seidl et al, 2014 for a review). In primary human neurons, Pomegranate juice (PJ) extract was found to regulate redox metabolism and thereby confer neuroprotection (Braidy et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

An in silico investigation on the inhibitory potential of the constituents of Pomegranate juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases

2019

Self Cite

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Elevation in the levels of reactive oxygen and nitrogen species (RONS), and downregulation of cellular antixoidants, have ubiquitously been reported from studies in animal models of neurodegenerative diseases, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Thus, plant-derived compounds are widely being investigated for their beneficial effects in these models. However, while studies have reported antioxidant potentials of several phytochemicals, a large number of studies have demonstrated different phytochemicals to be rather pro-oxidant and exaggerate oxidative stress (OS). One such study aimed to investigate possible ameliorative effect of Pomegranate juice (PJ) in rat model of toxin-induced parkinsonism revealed that PJ exacerbates OS, inflammation and promotes neurodegeneration. Thus, it remains to be investigated whether different constituents and metabolites of PJ are pro-oxidant or anti-oxidant. Using computational modeling, we investigated possible inhibitory potential of different constituents of PJ and their metabolites viz. delphinidin-3-glucoside, dimethylellagic acid-glucuronide, ellagic acid, ellagitannin, gallic acid, gallotannin 23, pelargonidin, punicalagin, urolithin A, urolithin A-glucuronide and urolithin B, on anti-oxidant defense system of the brain. The results indicate that the constituents of PJ have the potential to inhibit five key enzymes of the neuronal antioxidant defense system, viz. catalase, superoxide dismutase, glutathione peroxidase 4, glutathione reductase and glutathione-S-transferase. Thus, it is surmised that the constituents of PJ may contribute to OS and neurodegeneration by way of affecting antioxidant defense mechanism. This may particularly be more pronounced in neurodegenerative diseases, since neurons are known to be more vulnerable to OS. Thus, the present findings caution the use of PJ in patients prone to OS, especially those suffering from neurodegenerative diseases, and warrant further experimental studies to unveil the effects of individual components and metabolites of PJ on antioxidant defense system of brain.

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“…In silico studies on the molecular interaction between garcinol and the active sites of COMT and MAO-B revealed that garcinol can potentially inhibit the activity of the two enzymes, similar to their known inhibitors [93]. In conclusion, garcinol may prove to be a dependable remedial measure in PD therapeutics since its inhibition of MAO-B and COMT can be correlated to increase the availability of dopamine as well as prevent the generation of toxic dopamine metabolites including homocysteine, 3-omethyldopa, 3-methoxytyramine, and 3,4-dihydroxyphenylacetaldehyde [98] (Figure 5).…”

Section: Garcinol From Garcinia Indica Choisymentioning

confidence: 73%

Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders

Lal¹,

Lal²

2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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The present review gives an account of various bioactive molecules obtained from Indian medicinal plants for neurological degenerative disorders. Emphasis is laid on their correlation with the plants used in traditional system of medicine in India. The methodology involved in present review was enlisting of medicinal plants used for neurodegenerative disorders followed by their chemistry. A correlation with the chemical constituents and their recent findings has been done. Many medicinal plants such as Aloe vera and Bacopa monnieri have documented correlations and also need to be explored more. Molecules like garcinol (34), which was originally an anticancer compound, have good correlation as neuroprotective agent. Likewise many plants that have not been explored but are used in traditional system of medicine have also been listed. Jaggery and honey, which are used in traditional formulations in large quantity, also have natural products that are used as neuroprotective agents. In conclusion, a lot more study is required to correlate the medicinal plants and herbal formulations to have much more natural products for neurodegenerative disorders.

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Garcinol, a multifaceted sword for the treatment of Parkinson's disease

Cited by 33 publications

References 91 publications

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

An in silico investigation on the inhibitory potential of the constituents of Pomegranate juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases

Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders

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