Garcinia morella extract confers dopaminergic neuroprotection by mitigating mitochondrial dysfunctions and inflammation in mouse model of Parkinson’s disease

Dutta, Ankumoni; Phukan, Banashree Chetia; Roy, Rubina; Mazumder, Muhammed Khairujjaman; Paul, Rajib; Choudhury, Amarendranath; Kumar, Diwakar; Bhattacharya, Pallab; Nath, Joyobrato; Kumar, Sanjeev; Borah, Anupom

doi:10.1007/s11011-022-01001-9

Cited by 4 publications

(3 citation statements)

References 90 publications

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“…SH-SY5Y cells are a good candidate for in vitro PD models. Rot, an inhibitor of the mitochondrial complex, can increase oxidative stress and neuroinflammation in SH-SY5Y cells. − In the present study, Rot-treated SH-SY5Y cells exhibited morphological changes and differential expression of numerous PD-related neuronal markers and increased intracellular oxidative stress, indicating that a PD model was successfully established. Our results revealed that mangiferin could reduce the cell injury caused by Rot in SH-SY5Y cells.…”

Section: Discussionsupporting

confidence: 48%

Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense

Zhou

Zhang

et al. 2023

ACS Chem. Neurosci.

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Parkinson's disease (PD), known as a neurodegenerative disease, is characterized by movement disorders, with increasing age being the predominant risk factor for its development. Mangiferin, a bioactive compound isolated from mango, shows potent neuroprotection. In our work, we investigated the neuroprotection and mechanisms of mangiferin against PD. We established PD models by treating SH-SY5Y cells with rotenone and mice with 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP) and investigated the therapeutic effects of mangiferin. Our results showed that mangiferin exhibited a cell-protective effect. Mangiferin also improved the motor behavior and attenuated the activation of microglia and astrocytes in MPTP mice. In addition, mangiferin decreased reactive oxygen species (ROS) levels and increased glutathione (GSH) and superoxide dismutase (SOD). Mangiferin also markedly activated GIT1, p-ERK, Nrf2, HO-1, and SOD expression and inhibited Keap1 expression in vitro and in vivo. To further investigate the role of GIT1, GIT1 siRNA was used. In the presence of GIT1 siRNA, the neuroprotection of mangiferin in PD was weakened. Our results indicate that mangiferin exhibited its therapeutic effect against PD by regulating GIT1 and its downstream Keap1/Nrf2 pathways. Our studies exhibited that mangiferin showed neuroprotection in PD, and its main target was GIT1. What is more, mangiferin could reduce the oxidative stress of PD by targeting GIT1 and its downstream Keap1/Nrf2 pathways. These indicated that mangiferin is a good candidate for PD therapy. However, the role of p-ERK in mangiferin-treated PD requires further investigation.

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Section: Discussionsupporting

confidence: 48%

Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense

Zhou

Zhang

et al. 2023

ACS Chem. Neurosci.

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“…Mitochondrial impairments also affect skeletal muscles and platelets cells, which explains the progressive motor impairment suffered during PD [ 53 ]. All of the above has been considered the primary mechanism of dopaminergic neurodegeneration in PD [ 58 ].…”

Section: Pathogenesis and Main Biological Mechanisms Of Neurodegenera...mentioning

confidence: 99%

“… Main mechanisms through which plant extracts and their phenolic compounds exert their neuroprotective effects, as well as key cell processes involved. Finally, several references in which this information is demonstrated [ 30 , 34 , 41 , 48 , 57 , 58 , 75 , 79 , 80 , 81 , 85 , 86 , 87 , 88 , 89 , 92 , 93 , 95 , 102 , 108 , 110 , 115 , 123 , 130 , 131 ]. …”

Section: Figurementioning

confidence: 99%

Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

et al. 2023

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Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation. Neurodegeneration affects millions of people worldwide, and no integral cure has been created yet. Here, bioactive compounds have been proven to exert numerous beneficial effects due to their remarkable bioactivity, so they could be considered as great options for the development of new neuroprotective strategies. Phenolic bioactives have been reported to be found in edible part of plants; however, over the last years, a large amount of research has focused on the phenolic richness that plant by-products possess, which sometimes even exceeds the content in the pulp. Thus, their possible application as an emergent neuroprotective technique could also be considered as an optimal strategy to revalorize these agricultural residues (those originated from plant processing). This review aims to summarize main triggers of neurodegeneration, revise the state of the art in plant extracts and their role in avoiding neurodegeneration and discuss how their main phenolic compounds could exert their neuroprotective effects. For this purpose, a diverse search of studies has been conducted, gathering a large number of papers where by-products were used as strong sources of phenolic compounds for their neuroprotective properties. Finally, although a lack of investigation is quite remarkable and greatly limits the use of these compounds, phenolics remain attractive for research into new multifactorial anti-neurodegenerative nutraceuticals.

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Effects of polyphenol on motor function in mice with Parkinson’s disease: a systematic review and meta-analysis

Cao,

Tian,

Chu

et al. 2024

Critical Reviews in Food Science and Nutrition

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Garcinia morella extract confers dopaminergic neuroprotection by mitigating mitochondrial dysfunctions and inflammation in mouse model of Parkinson’s disease

Cited by 4 publications

References 90 publications

Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense

Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense

Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Effects of polyphenol on motor function in mice with Parkinson’s disease: a systematic review and meta-analysis

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