The future adoption of automated vehicles poses many challenges, with one of the more important being the preservation of control over vehicles that are no longer (fully) operated by drivers. There is consensus that vehicles should not perform actions that are unacceptable to humans. In this paper, we introduce the concept of Meaningful Human Control (MHC) as a function of a framework of the Automated Driving System (ADS). This framework is constructed through the core components that make up the ADS, primarily considered within the categories of the vehicle and driver. Identification of these components and the chain of control allow traceability of MHC to be performed, and aids vehicle manufacturers, software developers, other vehicle component designers, and vehicle-and driver licensing authorities to address many challenges related to the design and preservation of human control in automated vehicles. Operationalisation of MHC is discussed in the paper including a suggested approach that should aid understanding and the application of the concept. Four application examples are given and recommendations are made in regard to vehicle design, human machine interaction, transition of control, driver training, vehicle approval, and other topics. The framework and presented concept also allow researchers to identify areas to perform more explicit and relevant research and develop models that can be applied to perform projections of future impacts. Relevance to human factors/Relevance to ergonomics theory The preservation of control over vehicles that are no longer (fully) operated by drivers is of major importance and a highly relevant topic in human factors and ergonomics research. This paper introduces the concept of Meaningful Human Control (MHC) as a function of a framework of the Automated Driving System (ADS) to address some of these challenges. The framework is essential for the construction of the theory of MHC and the operationalisation in various field connected to human factors, HMI, automated vehicle software design. This aids vehicle manufacturers, software developers, other vehicle component