GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α

Chiche, Johanna; Pommier, Sébastien; Bénéteau, Marie; Mondragón, Laura; Meynet, Ophélie; Zunino, Barbara; Mouchotte, Annabelle; Verhoeyen, Els; Guyot, Mélanie; Pagès, Gilles; Mounier, Nicolas; Imbert, Véronique; Colosetti, P.; Gonçalves, Débora Farina; Marchetti, Sandrine; Brière, J; Carlès, Michel; Thiéblemont, Catherine; Ricci, Jean-Ehrland

doi:10.1038/leu.2014.324

Cited by 57 publications

(55 citation statements)

References 39 publications

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“…In turn, NF-κB activation required the accumulation of the HIF-1α protein under hypoxic conditions 44 . There is also evidence showing that NF-κB promotes the transcription and activity of HIF-1α in several cancers 45,46 . In addition, interventions aimed at HIF-1α consistently lead to the simultaneous inactivation of the NF-κB pathway 47 .…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Wang

Gao

et al. 2020

Cell Death Dis

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Hypoxia is a critical factor in the malignant progression of glioma, especially for the highly-invasive mesenchymal (MES) subtype. But the detailed mechanisms in hypoxia-induced glioma MES transition remain elusive. Pseudogenes, once considered to be non-functional relics of evolution, are emerging as a critical factor in human tumorigenesis and progression. Here, we investigated the clinical significance, biological function, and mechanisms of protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) in hypoxia-induced glioma MES transition. In this study, we found that PDIA3P1 expression was closely related to tumor degree, transcriptome subtype, and prognosis in glioma patients. Enrichment analysis found that high PDIA3P1 expression was associated with epithelial-mesenchymal transition, extracellular matrix (ECM) disassembly, and angiogenesis. In vitro study revealed that overexpression of PDIA3P1 enhanced the migration and invasion capacity of glioma cells, while knockdown of PDIA3P1 induced the opposite effect. Further studies revealed that PDIA3P1 functions as a ceRNA, sponging miR-124-3p to modulate RELA expression and activate the downstream NF-κB pathway, thus promoting the MES transition of glioma cells. In addition, Hypoxia Inducible Factor 1 was confirmed to directly bind to the PDIA3P1 promotor region and activate its transcription. In conclusion, PDIA3P1 is a crucial link between hypoxia and glioma MES transition through the PDIA3P1-miR-124-3p-RELA axis, which may serve as a prognostic indicator and potential therapeutic target for glioma treatment.

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Section: Discussionmentioning

confidence: 99%

Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Wang

Gao

et al. 2020

Cell Death Dis

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“…The glycolytic pathway involves the conversion of glucose to lactate and the generation of ATP via a series of 10 enzymes (Chiche et al, 2015). Glucose transporter-1 (GLUT1) and hexokinase-2 (HK2) are among the major proteins regulating the transportation and transformation of glucose, respectively, and their expression level and function status are of great significance in the glucose metabolism in cancer cells.…”

Section: Afm Increases the Expressions Of Glut1 And Hk2 In Papillary mentioning

confidence: 99%

Afamin promotes glucose metabolism in papillary thyroid carcinoma

Shen

Wei

Qiu

et al. 2016

Molecular and Cellular Endocrinology

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“…NF-κB expression in tumor tissues is significantly correlated with HIF-1α expression, VEGF expression, and the presence of vascular invasion [31]. Inhibitors of NF-κB, such as BAY11-7028, can suppress HIF-1α and VEGF [32].…”

Section: Discussionmentioning

confidence: 99%

Dihydroartemisinin Increases the Sensitivity of Photodynamic Therapy Via NF-κB/HIF-1α/VEGF Pathway in Esophageal Cancer Cell in vitro and in vivo

Sui

Jiang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Although photodynamic therapy (PDT) can relieve esophageal obstruction and prolong survival time of patients with esophageal cancer, it can induce nuclear factor-kappa B (NF-κB) activation in many cancers, which plays a negative role in PDT. Dihydroartemisinin (DHA), the most potent artemisinin derivative, can enhance the effect of PDT on esophageal cancer cells. However, the mechanism is still unclear. Methods: We generated stable cell lines expressing the super-repressor form of the NF-κB inhibitor IκBα and cell lines with lentivirus vector-mediated silencing of the HIF-1α gene. Esophageal xenograft tumors were created by subcutaneous injection of Eca109 cells into BALB/c nude mice. Four treatment groups were analyzed: a control group, photosensitizer alone group, light alone group, and PDT group. NF-κB expression was detected by an electrophoretic mobility shift assay, hypoxia-inducible factor α (HIF-1α) and vascular endothelial growth factor (VEGF) by real-time PCR, NF-κB, HIF-1α, and VEGF protein by western blot, and Ki-67, HIF-1α, VEGF, and NF-κB protein by immunohistochemistry. Results: PDT increased NF-κB activity and the gene expression of HIF-1α and VEGF in vitro and in vivo. In contrast, the DHA groups, particularly the combined DHA and PDT treatment group, abolished the effect. The combined treatment significantly inhibited tumor growth in vitro and in vivo. NF-κB activity and HIF-1α expression were also reduced in the stable IκBα expression group, whereas the former showed no change in HIF-1α-silenced cells. Conclusion: DHA might increase the sensitivity of esophageal cancer cells to PDT by inhibiting the NF-κB/HIF-1α/VEGF pathway.

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GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α

Cited by 57 publications

References 39 publications

Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Afamin promotes glucose metabolism in papillary thyroid carcinoma

Dihydroartemisinin Increases the Sensitivity of Photodynamic Therapy Via NF-κB/HIF-1α/VEGF Pathway in Esophageal Cancer Cell in vitro and in vivo

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