Gap detection threshold in the rat before and after auditory cortex ablation

Syka, Josef; Rybalko, Natalia; Mazelová, Jana; Druga, R

doi:10.1016/s0378-5955(02)00578-6

Cited by 62 publications

(79 citation statements)

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“…The results of the gap detection measurements showed the same GDT values in young adult rats as we found in previous experiments [18,19], with a significant worsening of the GDT values in old rats when they increased almost two-fold (by 89%). The age-related increase in the gap detection threshold (1.8 ms in young and 3.4 ms in old rats) had a similar magnitude as reported in mice [28], gerbils [29] and man [4,5,10,14].…”

Section: Accepted M Manuscriptsupporting

confidence: 87%

“…The same phenomenon of increased GDT variability in elderly subjects was also observed in gerbils [29], mice [28] and in man [9,28] Several studies have demonstrated that the intensity and frequency content of the carrier noise play an important role in gap detection: GDT values markedly increase (both in man and in animals) when the signal audibility is low (when the noise intensity is less than 25-30 dB sensation level) or when the noise spectrum is restricted to low frequencies [1,8,18,45].…”

Section: Accepted M Manuscriptmentioning

confidence: 55%

“…Similarly as in normal hearing subjects, an intensity of the carrier sound above a 20-30 dB sensation level is required for reliable GDT measurements in old [29] as well as in hearing-impaired subjects [18,46]. With respect to the results of our previous study [47] and the results of other authors showing that the increase of hearing thresholds in old rats amounts to 30-40 dB [34,48,49], we measured GDT and GDDL at a carrier noise intensity of 75 dB SPL.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…As a behavioral method for assessing auditory temporal resolution in animals, the gap detection task has been frequently used (e.g., rat [17][18][19], mice [20,21], chinchilla [22,23]; ferret [23], gerbil [25], starling [26], budgerigar and zebra finch [27]. A deficit in gap detection with aging was demonstrated in mice [20,28] and gerbils [29].…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

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ACCEPTED MANUSCRIPTABBREVIATIONS: dB SPL -dB sound pressure level, GDDL -gap duration difference limen, GDT-gap detection threshold, MLR -middle latency response ABSTRACT Presbycusis, as the deterioration of hearing ability occurring with aging, can be manifested not only in a shift of hearing thresholds, but also in a deterioration of the temporal processing of acoustical signals, which may in elderly people result in degraded speech comprehension.In this study we assessed the age-related changes in the temporal processing of acoustical signals in the auditory system of pigmented rats (Long Evans strain). The temporal resolution was investigated in young adult (3-4 months) and old (30-34 months) rats by behavioral and electrophysiological methods: the rats' ability to detect and discriminate gaps in a continuous noise was examined behaviorally, and the amplitude-rate function was assessed for the middle latency response (MLR) to clicks. A worsening of the temporal resolution with aging was observed in the results of all tests. The values of the gap detection threshold (GDT) and the gap duration difference limen (GDDL) in old rats increased about two-fold in comparison with young adult rats. The MLR to a click train in old rats exhibited a significantly faster reduction in amplitude with an increasing stimulation rate in comparison with young adult rats. None of the age-related changes in the parameters characterizing temporal resolution (GDT, GDDL and MLR to a click train) correlated with the degree of the age-related hearing loss. However, the age-related changes in MLR amplitude-rate function correlated with the age-related changes in GDDL, but not with the changes in GDT. The behavioral and electrophysiological data clearly show that aging in rats is accompanied with a pronounced deficit in the temporal processing of acoustical signals that is associated with the deteriorated function of the central auditory system.

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Section: Accepted M Manuscriptsupporting

confidence: 87%

Section: Accepted M Manuscriptmentioning

confidence: 55%

Section: Accepted M Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

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“…Neural correlates of gap detection have been demonstrated in the frog auditory system (Feng et al, 1994) and various mammalian species including chinchilla (Giraudi et al, 1980, GiraudiPerry et al, 1982Salvi and Arehole, 1985), rat (Syka et al, 2002;Rybalko and Syka, 2005), mouse (Barsz et al, 2002;Walton et al, 2002;Allen et al, 2003), gerbil (Wagner et al, 2003), ferret (Kelly et al, 1996), and cat (Eggermont, 1999(Eggermont, , 2000 using a variety of behavioral and electrophysiological paradigms. A study comparing behavioral and auditory brainstem response (ABR) gap detection thresholds showed the two thresholds to be similar, with the ABR thresholds tending to be lower (Werner et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Encoding of temporal features of auditory stimuli in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat

2008

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Neurons in the superior paraolivary nucleus (SPON) respond to the offset of pure tones with a brief burst of spikes. Medial nucleus of the trapezoid body (MNTB) neurons, which inhibit the SPON, produce a sustained pure tone response followed by an offset response characterized by a period of suppressed spontaneous activity. This MNTB offset response is duration dependent and critical to the formation of SPON offset spikes (Kadner et al., 2006;Kulesza, Jr. et al., 2007). Here we examine the temporal resolution of the MNTB/SPON circuit by assessing its capability to i) detect gaps in tones, and ii) synchronize to sinusoidally amplitude modulated (SAM) tones. Gap detection was tested by presenting two identical pure tone markers interrupted by gaps ranging from 0-25 ms duration. SPON neurons responded to the offset of the leading marker even when the two markers were separated only by their ramps (i.e., a 0 ms gap); longer gap durations elicited progressively larger responses. MNTB neurons produced an offset response at gap durations of 2 ms or longer, with a subset of neurons responding to 0 ms gaps. SAM tone stimuli used the unit's characteristic frequency as a carrier, and modulation rates ranged from 40-1160 Hz. MNTB neurons synchronized to modulation rates up to ~1 KHz, whereas spiking of SPON neurons decreased sharply at modulation rates ≥ 400 Hz. Modulation transfer functions based on spike count were all-pass for MNTB neurons and low-pass for SPON neurons; the modulation transfer functions based on vector strength were low-pass for both nuclei, with a steeper cut-off for SPON neurons. Thus, the MNTB/SPON circuit encodes episodes of low stimulus energy, such as gaps in pure tones and troughs in amplitude modulated tones. The output of this circuit consists of brief SPON spiking episodes; their potential effects on the auditory midbrain and forebrain are discussed.

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Long‐term regulation in calretinin staining in the rat inferior colliculus after unilateral auditory cortical ablation

Clarkson¹,

Juı́z²,

Merchán³

2010

J of Comparative Neurology

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In this study we analyzed the effects in the inferior colliculus of a unilateral ablation of the auditory cortex in rats. Variations in both calretinin immunoreactivity and protein levels determined by Western blot suggest that such lesions induce changes in the regulation of this calcium-binding protein. Stereological counts of calretinin-immunoreactive neurons in the inferior colliculus 15, 90, and 180 days after the lesion showed a progressive increase in the number of immunoreactive neurons, with a parallel increase in the intensity of staining. Two hundred forty days after the cortical lesion, both the number of immunoreactive neurons and the staining intensity had returned to control values. The effects of the cortical lesion on calretinin regulation are more intense in those inferior colliculus subdivisions more densely innervated by the corticocollicular projection. This finding, along with the time course of calretinin regulation suggests that degeneration of the descending projection is linked to calretinin regulation in the inferior colliculus. We hypothesize, based on the role of calretinin, that the observed increase in immunoreactivity levels seen in the inferior colliculus after lesioning of the auditory cortex may be related to altered excitability in deafferented neurons. Our finding, may reflect adaptive mechanisms to changes in calcium influx and excitability in inferior colliculus neurons induced by lesions of the descending projection from the cortex to the inferior colliculus.

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Gap detection threshold in the rat before and after auditory cortex ablation

Cited by 62 publications

References 41 publications

Age-related changes in auditory temporal processing in the rat

Age-related changes in auditory temporal processing in the rat

Encoding of temporal features of auditory stimuli in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat

Long‐term regulation in calretinin staining in the rat inferior colliculus after unilateral auditory cortical ablation

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