Ganzkörperkryotherapie bei Patienten mit entzündlich-rheumatischen Erkrankungen

Braun, K.-P.; Brookman-Amissah, S.; Geißler, Katrin; Ast, Doris; May, Matthias; Ernst, H.

doi:10.1007/s00063-009-1031-9

Cited by 27 publications

(15 citation statements)

References 2 publications

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“…As for the five noncontrolled studies, the mean NOS quality score was 5 ± 1.2 [63,64,[66][67][68]. Overall, the mean JADAD11 score for the six selected studies was 4.8 ± 1.9.…”

Section: Results: Study Quality Assessmentmentioning

confidence: 99%

“…There was one RCT with 40 patients meeting the inclusion criteria [70], two controlled trials [63,64], two studies comparing parallel cryotherapy treatment groups [67,68] and one noncontrolled study [66].…”

Section: Results: Study Quality Assessmentmentioning

confidence: 99%

“…VAS (A) and DAS28 (B). Mean differences in pain VAS (mm) or DAS28 before/after LC or WBC are represented for each of the six studies included in the meta-analysis [63,64,[66][67][68]70], with 95% confidence intervals. Heterogeneity was also tested using Fisher's test (F0 and p-values are shown on the graphs).…”

Section: Results: Heterogeneity Assessmentmentioning

confidence: 99%

“…There were five RCTs, two nonrandomized controlled studies, three studies comparing several cryotherapy techniques in parallel treatment arms and three noncontrolled studies. Seven articles dealt with local cryotherapy [8,[59][60][61][62][63][64], four with WBC [65][66][67][68] and two with both (FIGURE 1) [69,70].…”

Section: Article Selection Processmentioning

confidence: 99%

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Cryotherapy in inflammatory rheumatic diseases: a systematic review

Guillot¹,

Tordi²,

Mourot³

et al. 2013

Expert Review of Clinical Immunology

103

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The aim of this article was to review current evidence about cryotherapy in inflammatory rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we performed a systematic review (PubMed, EMBASE, Cochrane Library, LILACS databases, unpublished data) and selected studies including non-operated and non-infected arthritic patients treated with local cryotherapy or whole-body cryotherapy. By pooling 6 studies including 257 rheumatoid arthritis (RA) patients, we showed a significant decrease in pain visual analogic scale (mm) and 28-joint disease activity score after chronic cryotherapy in RA patients. For molecular pathways, local cryotherapy induces an intrajoint temperature decrease, which might downregulate several mediators involved in joint inflammation and destruction (cytokines, cartilage-degrading enzymes, proangiogenic factors), but studies in RA are rare. Cryotherapy should be included in RA therapeutic strategies as an adjunct therapy, with potential corticosteroid and nonsteroidal anti-inflammatory drug dose-sparing effects. However, techniques and protocols should be more precisely defined in randomized controlled trials with stronger methodology.

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“…As for the five noncontrolled studies, the mean NOS quality score was 5 ± 1.2 [63,64,[66][67][68]. Overall, the mean JADAD11 score for the six selected studies was 4.8 ± 1.9.…”

Section: Results: Study Quality Assessmentmentioning

confidence: 99%

Section: Results: Study Quality Assessmentmentioning

confidence: 99%

Section: Results: Heterogeneity Assessmentmentioning

confidence: 99%

Section: Article Selection Processmentioning

confidence: 99%

See 2 more Smart Citations

Cryotherapy in inflammatory rheumatic diseases: a systematic review

Guillot¹,

Tordi²,

Mourot³

et al. 2013

Expert Review of Clinical Immunology

103

View full text Add to dashboard Cite

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“…, und die ser sank auf 3,4 ab[32], sodass gegenwär tig unklar bleibt, ob eine Ganzkörperkäl tetherapie die Krankheitsaktivität der RA günstig beeinflussen kann.In den Studien zur Evaluation der Ganz körperkältetherapie brachen bis zu 22% der Patienten die Therapie ab, wobei eine subjektive Unverträglichkeit als häufigs ter Abbruchgrund genannt wurde[17,32]. In weniger als 5% traten ein unkont rollierbarer Blutdruckanstieg, Unwohl sein, Urtikaria oder ein Infekt als Neben wirkung auf und führten bei einem Teil der Fälle ebenfalls zu einem Therapie abbruch.Die lokale Kryotherapie ist eine experimentell gut abgesicherte Methode zur Senkung der Temperatur von oberfläch-lichen und tiefen Gewebsschichten und führt zur Hemmung der neuronalen Aktivität sowie zur Vasokonstriktion.…”

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Kryotherapie

Hermann

2009

Z. Rheumatol.

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Cryotherapy is a form of physical therapy that can be applied locally and systemically. Local cryotherapy administered for instance as cold packs, cold air or sprays lowers skin and tissue temperature and subsequently decreases neuronal activity and tissue blood flow. In clinical trials cryotherapy showed analgetic effects and reduced local edema; this treatment is therefore an option in patients with painful and inflammatory rheumatic diseases and after traumatic injuries.Only scant experimental and clinical data are available for whole body cryotherapy at -110 degrees C. The analgetic effects demonstrated so far and the high percentage of adverse events observed with this challenging method currently do not support its routine use in clinical practice.

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