Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Şöhretoğlu, Didem; Huang, Shile

doi:10.2174/1871520617666171113121246

Cited by 153 publications

(105 citation statements)

References 76 publications

(111 reference statements)

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“…These results indicated that animals treated with G. Lucidum cause a significant increase in the levels of antioxidant enzymes. These results are in line with the reports of other researchers that allude to the fact that Gandoderma lucidium has antioxidant activities both in vivo and in vitro [ 45 , 46 , 47 ]. These results indicated the hepatoprotective efficacy of G. Lucidum.…”

Section: Discussionsupporting

confidence: 93%

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Adetuyi¹,

Okeowo

Adetuyi

et al. 2020

Biology

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The majority of liver-related illnesses are caused by occupational and domestic exposure to toxic chemicals like formaldehyde (FA), which is widely common in Africa and the world at large. Hence, measures should be taken to protect humans from its hazardous effects. This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation in male rats. Male Wistar rats, 150–200 g, were allotted into four groups of 10 animals as follows: Group 1 was orally treated with 1 mg/mL distilled water, Group 2 was exposed to a 40% formaldehyde vapor environment for 30 min per day, Group 3 was orally treated with 100 mg/kg ethanol extract of Ganoderma lucidum, and Group 4 was co-administered formaldehyde and 100 mg/kg ethanol extract of Ganoderma lucidum. Rats were then sacrificed 24 h after administering the last dose of treatment, and the livers were excised. Ganoderma lucidum significantly reversed the formaldehyde-mediated reduction in body and organ weight. Ganoderma lucidum administration significantly prevented oxido-inflammation by reducing the levels of hydrogen peroxide and malondialdehyde and increasing the activity of antioxidant enzymes and glutathione contents, as well as the normal level of nitrite and myeloperoxidase production in FA-treated rats. Additionally, Ganoderma lucidum reversed a large decline in proinflammatory markers in formaldehyde. Furthermore, Ganoderma lucidum restores formaldehyde-induced histological alterations in the liver. Collectively, our results provide valuable information on the protective potential of Ganoderma lucidum in protecting formaldehyde-induced liver oxido-inflammation in male rats.

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Section: Discussionsupporting

confidence: 93%

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Adetuyi¹,

Okeowo

Adetuyi

et al. 2020

Biology

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“…GL has been used in the treatment of various diseases, such as allergy, arthritis, bronchitis, gastric ulcer, hyperglycemia, hypertension, chronic hepatitis, insomnia, nephritis, nerve weakness, inflammation, and cancer (24).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues

2019

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Aim:The purpose of this study was to determine whether extremely low frequency electric and magnetic field (ELF-EMF) had any detrimental effects on periodontal tissue and to investigate, histologically and immunohistochemically whether melatonin (MLT) and Ganoderma lucidum (GL) had a protective role against these detrimental effects. Methodology:A total of 56 adults, male Wistar Albino rats were used in this study. Rats were divided into 7 equal groups and exposed to ELF-EMF, which was produced by a high voltage source, 8 hours / day for 26 days. GL (20 mg / kg / day) and MLT (10 mg / kg / day) were administered by the oral gavage and intraperitoneal method. Results: Fibrous degeneration in the periodontal membrane, inflammatory cell infiltration, connective tissue fiber organization, dilation, and hemorrhage in the blood vessels changes were determined in the periodontal tissue of the rats in groups I and IV. A statistically significant difference was determined in the groups treated with MLT and GL (p<0.05). Conclusions: It has been determined that ELF-EMF exposure causes histological changes in the periodontal tissue of rats and that MLT and GL may protect against these effects. How to cite this article: Gül M, Yavaş MC, Dündar S. Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues. Int Dent Res 2019;9(3):119-26. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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“…However, there is also evidence of prebiotic activity on the microbiota, although this could be secondary to a direct effect on immune system components. Its powerful immunomodulatory effects led to extend its field of use also to the therapy of tumors, a topic which, however, goes beyond the themes of this chapter [138]. In DSS-induced colitis in rats, G. lucidum β-glucans increased SCFA-producing bacteria such as Ruminococcus, and reduced pathobionts such as Escherichia and Shigella in both the small intestine and cecum [139].…”

Section: Microbiota-modulating Fungimentioning

confidence: 99%

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

Spisni¹,

Turroni²,

Shahaj³

et al. 2021

Alternative Medicine - Update

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Clinical interest in the human gut microbiota has increased considerably, because of the increasing number of studies linking the human intestinal microbiota and microbiome to an ever increasing number of non-communicable diseases. Many attempts at modulating the gut microbiota have been made using probiotics and prebiotics. However, there are other avenues that are still little explored from a clinical point of view that appear promising to obtain modifications of the microbial ecology and biological activities connected to the microbiome. This chapter summarizes all in vitro, in vivo and clinical studies demonstrating the possibility to positively modulate the intestinal microbiota by using probiotics, foods (and prebiotics), essential oils, fungus and officinal plants. For the future, clinical studies investigating the ability to modify the intestinal microbiota especially by using foods, officinal and aromatic plants or their extracts are required. More knowledge in this field is likely to be of clinical benefit since modulation of the microbiome might support the therapy of most non-communicable diseases in the future.

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Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Cited by 153 publications

References 76 publications

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

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