Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation.

Kim, K C; Kim, I G

doi:10.3892/ijmm.4.3.273

Cited by 40 publications

(33 citation statements)

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“…Our investigation found that only protein extract from the fungal mycelia showed such property but not protein extract from its fruiting bodies. The difference of ability in protecting against DNA strand break induced by hydroxyl radicals between previous reported (Kim and Kim 1999) and our investigation may due to differences in other composition of the fruiting bodies protein extract, i.e. polysaccharides, polyphenols and etc..…”

Section: Antibacterial Activitycontrasting

confidence: 83%

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Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum

et al. 2014

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Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial and DNA protective activities. It was found that the half maximal inhibitory concentration (IC 50 ) of the mycelia protein and fruiting bodies protein extracts against 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical (ABTS •+ ) were 2.47±0.01 and 2.77±0.11 μg protein/ml and against 2,2-diphenylpicrylhydrazyl radical (DPPH • ) were 2.5 ±0.01 and 3.42±0.01 μg protein/ml, respectively. The ferric reducing-antioxidant power (FRAP) values of those samples were 1.73±0.01 and 2.62±0.01 μmole trolox/μg protein respectively. Protein hydrolysates prepared by pronase exhibited a weaker antioxidant activity. Both crude proteins showed antibacterial activity, whereas only the mycelia protein extract could protect DNA damage by hydroxyl (• OH) radicals. This protein extract was partial purified by Diethyl amino ethyl (DEAE)-Sepharose column and Sulfopropyl (SP)-Sepharose column, obtained major protein with molecular weight about 45 kilo Dalton (kDa). In conclusion, G. lucidum protein extracts have promise potential for applications as antioxidant and antibacterial agents.

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Section: Antibacterial Activitycontrasting

confidence: 83%

“…Polysaccharide extracted from G. lucidum fruiting bodies has been reported in protecting against hydroxyl radical-induced DNA strand breaks (Kim and Kim 1999). Our investigation found that only protein extract from the fungal mycelia showed such property but not protein extract from its fruiting bodies.…”

Section: Antibacterial Activitymentioning

confidence: 48%

Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum

et al. 2014

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“…Previous investigations in our laboratory showed that G. lucidum occurring in South India possessed significant antioxidant, antitumor, anti-inflammatory, antinociceptive, nephroprotective and radioprotective properties (Jones and Janardhanan 2000;Sheena et al 2003a, b;Lakshmi et al 2003;Pillai et al 2008). G. lucidum is also reported to possess significant antioxidant and DNA protective effects (Kim and Kim 1999;Lee et al 2001). However, no reports are available on the effect of G. lucidum on the Krebs cycle enzymes and electron transport chain complexes on the heart mitochondria of aged animals.…”

Section: Introductionmentioning

confidence: 89%

Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat

2009

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Aging is associated with increased oxidative damage at multiple cellular levels, decline in cellular energy production and enhanced free radical status. The effect of the medicinal mushroom, Ganoderma lucidum on the activities of tricarboxylic acid (Krebs) cycle enzymes and mitochondrial complexes I-IV of the electron transport chain in aged rats were investigated. The activity of Krebs cycle enzymes, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase as well as mitochondrial complexes I, II, III, and IV were determined in heart of aged male Wistar rats orally administrated with 70% ethanolic extract (50 and 250 mg/kg) of G. lucidum. DL-alpha-lipoic acid (100 mg/kg) was taken as the positive control. Administration of the G. lucidum, once daily for 15 days, was significantly (P < 0.05) effective to enhance the Krebs cycle dehydrogenases, and mitochondrial electron transport chain complex IV activities in aged rats. The profound activity of the extract can be correlated to the significant antioxidant property of G. lucidum. The results of the study revealed that G. lucidum is effective to ameliorate the age associated decline of cellular energy status.

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“…Kim and kim (1999) reported that mushroom extracts possess DNA protecting properties. G. lucidum extracts can trap number of free radicals (Jones and Janardhanan, 2000).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Nutritional and medicinal importance of mushrooms

Wani¹,

Bodha²,

Wani³

2010

J. Med. Plants Res.

231

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Mushrooms had long been used for medicinal and food purposes since decades. It is now increasingly recognized that correct diet, controls and modulates many functions of human body and consequently participates in the maintenance of state of good health, necessary to reduce the risk of many diseases. Modern pharmacological research confirms large parts of traditional knowledge regarding the medicinal effects of mushrooms due to their antifungal, antibacterial, antioxidant and antiviral properties, besides being used as functional foods. This paper sums up diverse beneficial health effects of mushrooms to humans, in the form of proteins, carbohydrates, fats, vitamins, minerals, food and drugs, and medicines.

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Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation.

Cited by 40 publications

References 0 publications

Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum

Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum

Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat

Nutritional and medicinal importance of mushrooms

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