Abstract:Background: Ganoderic acid B is an important bioactive ingredient isolated from Ganoderma lucidum, and exhibits various pharmacological activities. Aims: To investigate the influence of Ganoderic acid B towards the therapeutic window of trifluoperazine (TFP). Methods: In vitro human liver microsomes (HLMs) incubation system was used to determine the inhibition of Ganoderic acid B towards the glucuronidation of trifluoperazine (TFP). Results: Ganoderic acid B exerted concentration-dependent inhibition towards t… Show more
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