Ganoderic Acid A Suppresses Androgenindependent Cell Growth via the AKT/GSK-3β/β-catenin Signaling Pathway
Qiao Lyu,
Yuan Qu,
Jianfan Chen
et al.
Abstract:Objective The primary aim of this study is to investigate the specific effects and mechanisms of ganoderic acid A (GAA) on castration-resistant prostate cancer (CRPC). Methods We successfully established an androgen-independent prostate cancer cell line (LNCaP-AI). The LNCaP-AI cells demonstrated accelerated growth, elevated levels of androgen receptor and prostate-specific antigen (PSA), and resistance to the drug enzalutamide. Then, we administered LNCaP-AI cells with GAA or a control and determined the cell… Show more
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