Gangrene of a Fetal Limb Due to Amniocentesis

Lamb, Martin

doi:10.1111/j.1471-0528.1975.tb00582.x

Cited by 45 publications

(5 citation statements)

References 4 publications

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“…This rapid fetal movement is very likely the reason for the virtual absence of fetal trauma during early second trimester amniocentesis. Although there are several reports of infants with minor scars, presumably due to necdle scratches at the time of genetic amniocentesis, there has been only one report of severe traumatic injury, and this involved a fetus with multiple congenital defects (Golbus et al 1974, Lamb 1975, Broome et al 1976).…”

Section: Discussionmentioning

confidence: 99%

Ultrasonography for guidance of amniocentesis in genetic counseling

1978

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Thc value of preliminary ultrasonography as a guide for amniocentesis in the early second trimester of pregnancy was prospectively evaluated. One hundred and fifty patients were altcrnately assigned to a control group or to an ultrasound group who underwent examination with a real-time scanner immediately prior to amniocentesis. All amniotic fluid samples were assessed as to the presence of blood by: (1) visual observation during the amniocentesis; (2) appearance of the centrifugate; and (3) microscopic analysis. Ultrasonography did not reduce the failure rate, the incidence of multiple needle insertions, or the proportion of amniotic fluid samples containing blood.

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Section: Discussionmentioning

confidence: 99%

Ultrasonography for guidance of amniocentesis in genetic counseling

1978

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“…Fetuses [Lamb, 1975] and children [Holmes, 1997] with limb abnormalities due to direct injury by amniocentesis needle have been reported. The physical effects were attributed to the needle injury itself.…”

Section: Amniocentesis Needlementioning

confidence: 99%

Teratogen‐induced limb defects

Holmes

2002

Am. J. Med. Genet.

100

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Limb abnormalities are one of the most common and visible phenotypic effects of several human teratogens. The specific effects are different for most teratogens and include effects on limb morphogenesis (thalidomide, warfarin, phenytoin, valproic acid) and the effect of vascular disruption on a limb that had formed normally (misoprostol, chorionic villus sampling, and phenytoin). Either duplication (preaxial polydactyly of hands and feet) or deficiency (absence of thumb) is a common effect of thalidomide; no other human teratogen identified to date has this effect on the developing limb. Procedures during pregnancy, including chorionic villus sampling and dilation and curettage, produce defects of vascular disruption. For common exposures, such as alcohol and cocaine, it has been difficult to confirm objectively the exposure during embryogenesis and to ascribe specific limb defects that are produced. The molecular basis for the limb defects produced by the recognized human teratogens remains unknown.

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“…tendon disruption (Epley et al 197Y) ~ neurological damage to a limb (Karp Kc Hayden 19771. and gangrcne of a limb (Lamb 1975) as a result of needle injury at mid-trimester amniocentesis. Although ultrasound preceded all procedures in thc present study, simultaneous real-time direction of the needle (Jeanty e/ al.…”

Section: Physicul Stutusmentioning

confidence: 99%

Infant outcome following mid‐trimester amniocentesis: development and physical status at age six months

Finegan

Quarrington

Hughes

et al. 1985

BJOG

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Summary. Ninety‐one infants whose mothers had had amniocentesis, because age increased their risk for a fetal chromosome abnormality, were compared with 53 infants whose mothers chose not to have the test. Mental and motor development and temperament were studied to assess potential influence of amniocentesis on the brain. Physical growth was assessed and the infants were examined for orthopaedic abnormalities and needle injury. The results indicated that amniocentesis does not appear to influence infant mental and motor development, temperament, physical growth or the risk of orthopaedic abnormalities. However, amniocentesis is not entirely free of risk because several of the infants had needle marks. Reassessment of the cohort at age 4 and 7 years and will provide information on the potential longer term consequences of mid‐trimester amniocentesis.

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Gangrene of a Fetal Limb Due to Amniocentesis

Abstract: Summary An unusual case of fetal damage after amniocentesis in the second trimester is described.

Cited by 45 publications

References 4 publications

Ultrasonography for guidance of amniocentesis in genetic counseling

Ultrasonography for guidance of amniocentesis in genetic counseling

Teratogen‐induced limb defects

Infant outcome following mid‐trimester amniocentesis: development and physical status at age six months

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