Abstract:The myelin sheath is an insulating, compacted, multilamellar biological membrane that facilitates efficient propagation of action potentials down neuronal axons, and is critical for proper physiological function. Recently, EM imaging has provided compelling in vivo data that puts to question the long-established mechanism for the formation of central nervous system (CNS) myelin. The new data have led to the proposal of a new model involving (1) the preformation of myelin membrane tubules that are trafficked to… Show more
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