Ganglionic acetylcholine receptor autoantibodies in patients with autoimmune diseases including primary biliary cirrhosis

Maeda, Yukihide; Nakane, Shunya; Higuchi, Osamu; Nakamura, Hideki; Komori, Atsumasa; Migita, Kiyoshi; Mukaino, Akihiro; Umeda, Masataka; Ichinose, Kunihiro; Tamai, Mami; Kawashiri, S.-Y.; Sakai, Waka; Yatsuhashi, Hiroshi; Kawakami, Atsushi; Matsuo, Hidenori

doi:10.1080/14397595.2016.1226469

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…As described above, sweating of SSc patients has been believed to be impaired because collagen accumulation causes atrophy of the sweat glands. Our unexpected results suggest the possibility that sweating is regulated by the autonomic nervous system (13,14), and it may be stimulated for unknown reasons in SSc patients. Alternatively, because skin sclerosis of the finger pads is usually mild, there may be compensatory hyperhidrosis.…”

Section: Discussionmentioning

confidence: 79%

Finger sweating levels evaluated by video capillaroscopy system are increased in patients with systemic sclerosis compared to pre-clinical stage patients

Tabata

Jinnin

Furukawa

et al. 2020

DD&T

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New strategies for early diagnosis and careful follow-up of systemic sclerosis are urgently needed. We unconventionally used a video capillaroscopy system to measure the amount of sweating on finger pads, and investigated its clinical significance. Thirty-three Japanese patients who were diagnosed with typical or pre-clinical stage patients of systemic sclerosis were included in this study. Five healthy subjects were also included. Among twenty-one patients with typical systemic sclerosis that fulfilled ACR/EULAR 2013 classification criteria, seven had increased sweating levels. On the other hand, among twelve pre-clinical stage patients that did not fulfill the classification criteria, no patient showed increase in finger sweating. We found that there was statistically significant difference. The ratio of diffuse cutaneous systemic sclerosis was also found to be significantly higher in subjects with increased amounts of sweating than in subjects with normal levels. Furthermore, the positivity of topoisomerase I antibody was statistically higher in patients with increased sweating levels than in those without. These results indicated that measurement of finger sweating levels may be a useful tool for early diagnosis and clarification of pathogenesis in this disease.

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Section: Discussionmentioning

confidence: 79%

Finger sweating levels evaluated by video capillaroscopy system are increased in patients with systemic sclerosis compared to pre-clinical stage patients

Tabata

Jinnin

Furukawa

et al. 2020

DD&T

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“…They include systemic lupus erythematosus (SLE), systemic sclerosis (SSc),, Still's disease, rheumatoid arthritis (RA), Hashimoto's disease and Graves’ disease, which often manifest skin symptoms. Recent studies revealed that gAChR antibodies were detected in sera from patients with SLE (12.5%), SSc (13.2%) and RA (18.6%), implicating the pathogenic significance of anti‐gAChR antibodies in these autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Case of autoimmune autonomic ganglionopathy manifesting anhidrosis

Yoshifuku

Yoneda

Sakiyama

et al. 2017

The Journal of Dermatology

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Autoimmune autonomic ganglionopathy (AAG), clinically characterized by gastrointestinal dysmotility, orthostatic hypotension and tonic pupils, is an idiopathic acquired disorder of the autonomic nervous system elicited by antibodies against ganglionic acetylcholine receptor (gAChR). We encountered a 60-year-old man who presented with severe anhidrosis, difficulty in thermoregulation, orthostatic hypotension, gastrointestinal dysmotility, tonic pupils and ptosis. Histologically, an anhidrotic skin sample was normal. Routine laboratory examinations of blood, urine and cerebrospinal fluid returned no abnormal findings. Serological examination revealed antibodies against α3 and β4 subunits of gAChR. The diagnosis was AAG. As sudomotor dysfunction reflects ganglionic neuropathy in AAG, we concluded that his anhidrosis was attributable to AAG. Anhidrosis is an important clue for the diagnosis of AAG, a rare neurological disorder.

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“…We determined the associations between autonomic dysfunction and anti-gAChR antibodies in SSc, SLE, and RA using the LIPS assay. The LIPS assay detected anti-gAChRα3 and β4 antibodies in the sera of patients with SSc (13.2%, 5/38), SLE (12.5%, 4/32), and RA (18.6%, 8/43) [17].…”

Section: Case Series and Prevalence Of Anti-gachr Antibodies In Systementioning

confidence: 99%

“…We performed the LIPS analysis with the α3 or β4 subunit fused to Gaussia Luciferase 8990 to measure the respective antibodies in human sera [9,14]. Recently, we determined the prevalence of anti-gAChR antibodies in autoimmune rheumatic diseases (ARD) including SS, SSc, RA, and SLE with this method [15][16][17]. In the present review, we aimed to critically examine the current literature on autonomic neuropathy and autonomic function tests and to propose that anti-gAChR antibodies provide a new perspective on the mechanism underlying autonomic dysfunction in ARD.…”

Section: Introductionmentioning

confidence: 99%

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

Imamura

Mukaino

Takamatsu

et al. 2020

IJMS

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Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjögren’s syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying autonomic dysfunction remains unknown to researchers. On the other hand, autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is mediated by autoantibodies against ganglionic acetylcholine receptors (gAChRs). The purpose of this review was to describe the characteristics of autonomic disturbance through previous case reports and the functional tests used in these studies and address the importance of anti-gAChR antibodies. We have established luciferase immunoprecipitation systems to detect antibodies against gAChR in the past and determined the prevalence of gAChR antibodies in various autoimmune diseases including AAG and rheumatic diseases. Autonomic dysfunction, which affects lower parasympathetic and higher sympathetic activity, is usually observed in ARD. The anti-gAChR antibodies may play a crucial role in autonomic dysfunction observed in ARD. Further studies are necessary to determine whether anti-gAChR antibody levels are correlated with the severity of autonomic dysfunction in ARD.

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Ganglionic acetylcholine receptor autoantibodies in patients with autoimmune diseases including primary biliary cirrhosis

Cited by 17 publications

References 18 publications

Finger sweating levels evaluated by video capillaroscopy system are increased in patients with systemic sclerosis compared to pre-clinical stage patients

Finger sweating levels evaluated by video capillaroscopy system are increased in patients with systemic sclerosis compared to pre-clinical stage patients

Case of autoimmune autonomic ganglionopathy manifesting anhidrosis

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

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