Ganglioneuromas in hamsters

Rustia, Mario; Cardesa, Antonio

doi:10.1007/bf00696794

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Furthermore, there were single cases described in the pituitary gland of an SD-derived rat (Pace and Perentes 2001) and an aged F344 rat (Okazaki et al 1997). Ganglioneuroma also may occur as a spontaneous neoplasm in hamsters (Rustia and Cardesa 1975) and has been shown to arise from the trigeminal ganglion in an aged B6C3F1 mouse (Yasui et al 2009). The malignant form of ganglioneuroma is the ganglioneuroblastoma, a neuroblastoma variant characterized by a small region of dark basophilic, oval, stemlike cells surrounded by ganglion cells.…”

Section: Ganglioneuroma and Ganglioneuroblastomamentioning

confidence: 99%

Section: Peripheral Nervous System Tumorsmentioning

confidence: 99%

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Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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Neoplasms of the nervous system, whether spontaneous or induced, are infrequent in laboratory rodents and very rare in other laboratory animal species. The morphology of neural tumors depends on the intrinsic functions and properties of the cell type, the interactions between the neoplasm and surrounding normal tissue, and regressive changes. The incidence of neural neoplasms varies with sex, location, and age of tumor onset. Although the onset of spontaneous tumor development cannot be established in routine oncogenicity studies, calculations using the time of diagnosis (day of death) have revealed significant differences in tumor biology among different rat strains. In the central nervous system, granular cell tumors (a meningioma variant), followed by glial tumors, are the most common neoplasms in rats, whereas glial cell tumors are observed most frequently in mice. Central nervous system tumors usually affect the brain rather than the spinal cord. Other than adrenal gland pheochromocytomas, the most common neoplasms of the peripheral nervous system are schwannomas. Neural tumors may develop in the central nervous system and peripheral nervous system from other cell lineages (including extraneural elements like adipose tissue and lymphocytes), but such lesions are very rare in laboratory animals.

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Section: Ganglioneuroma and Ganglioneuroblastomamentioning

confidence: 99%

Section: Peripheral Nervous System Tumorsmentioning

confidence: 99%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…In addition, only one case of ganglioneuroma derived from the cranial ganglion has been reported in a rat (Fitzgerald et al 1974). In hamsters, three cases of ganglioneuromas originating from the sympathetic ganglia have been published (Rustia and Cardesa 1975). To the best of our knowledge, however, there have been no reports of ganglioneuromas arising from any organs or tissues other than the adrenal glands in mice.…”

Section: Case Reportmentioning

confidence: 99%

Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse

et al. 2009

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In a carcinogenicity study, a neuronal tumor in the cranial cavity was observed in a 110-week-old female B6C3F1 mouse. At necropsy, the tumor was seen at the site of the pituitary gland. Histologically, the tumor consisted of well-differentiated ganglion cells, nerve fiber/neuropil-like elements and ganglion-like cells. The tumor was composed mainly of ganglion-like cells, which were arranged in solid sheets interspersed with thin fibrovascular stroma. Nissl substance was detected at the margin in the cytoplasm of well-differentiated ganglion cells, and nerve fibers were identified by the Kluever-Barrera method. Immunohistochemically, the well-differentiated ganglion cells were positive for S-100, neurofilament protein (NF), neuron-specific enolase (NSE), synaptophysin, and chromogranin A. The nerve fiber/neuropil-like elements were positive for S-100, NF, NSE, and glial fibrillary acidic protein (GFAP), and the ganglion-like cells were strongly positive only for NSE and synaptophysin. On the other hand, there were no pituitary cells, such as prolactin-positive or adrenocorticotropic hormone (ACTH)-positive cells in the tumor tissue. Detailed histopathological examination suggested that the tumor might be a ganglioneuroma arising from the trigeminal ganglion. This report provides additional histopathological evidence of peripheral nerve neoplasms in mice.

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Morphology of experimentally induced tumors of the sympathetic nervous system in rats

Бениашвили

Anisimov

2004

Experimental and Toxicologic Pathology

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Ganglioneuromas in hamsters

Cited by 7 publications

References 16 publications

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse

Morphology of experimentally induced tumors of the sympathetic nervous system in rats

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