Ganglion cell populations in normal and pathological human cochleae. Implications for cochlear implantation

Otte, Jorge; Schuknecht, Harold F.; Kerr, A. G.

doi:10.1002/lary.25219

Cited by 13 publications

(11 citation statements)

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“…Postmortem temporal bone studies demonstrate a reduction in SGN density with increasing age and duration of hearing loss (Makary et al, 2011;Nadol, 1997;Nadol et al, 1989;Otte et al, 1978). Histopathological data also show that hearing loss etiology, which often differs between child-and adult-deafened individuals, is a strong predictor of SGN density in humans (Nadol, 1997;Nadol et al, 1989;Otte et al, 1978). Available behavioral and electrophysiological evidence supports the temporal bone findings, suggesting that children with CIs have lower focused behavioral thresholds (DiNino, O'Brien, Bierer, Jahn, & Arenberg, 2019) and steeper ECAP AGFs (Brown et al, 2010) than adults.…”

Section: Polarity Sensitivity As a Function Of Age And Duration Of Deafnessmentioning

confidence: 72%

“…This prediction was based on human temporal bone literature and limited behavioral and electrophysiological evidence. Postmortem temporal bone studies demonstrate a reduction in SGN density with increasing age and duration of hearing loss (Makary et al, 2011;Nadol, 1997;Nadol et al, 1989;Otte et al, 1978). Histopathological data also show that hearing loss etiology, which often differs between child-and adult-deafened individuals, is a strong predictor of SGN density in humans (Nadol, 1997;Nadol et al, 1989;Otte et al, 1978).…”

Section: Polarity Sensitivity As a Function Of Age And Duration Of Deafnessmentioning

confidence: 95%

“…Children and adults with CIs also tend to have different hearing loss etiologies. Human histological studies demonstrate that chronological age, duration of deafness, and hearing loss etiology are each predictive of SGN density (Makary et al, 2011;Nadol, 1997;Nadol et al, 1989;Otte et al, 1978). The primary goal of this study was to expand upon previous literature by characterizing polarity sensitivity and speech perception performance in a relatively large and diverse sample of CI listeners.…”

Section: Introductionmentioning

confidence: 98%

“…Signal detection theory analysis suggests that a dramatic loss of SGNs ($75%) may be required to detect measurable, albeit small, deficits in psychoacoustic perception (Oxenham, 2016). Similarly, empirical data in humans do not demonstrate consistent relationships between postmortem SGN density and speech perception scores obtained during an individual's lifetime (Fayad & Linthicum, 2006;Khan et al, 2005;Nadol et al, 2001;Otte et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…Some of this variability may, in part, result from within-and acrosssubject variation in spiral ganglion neuron (SGN) integrity. Human postmortem temporal bone studies demonstrate that SGN density varies widely across individuals and across the length of the cochlea within an individual ear (Hinojosa & Marion, 1983;Makary, Shin, Kujawa, Liberman, & Merchant, 2011;Nadol, 1997;Nadol, Young, & Glynn, 1989;Otte, Schuknecht, & Kerr, 1978). In those temporal bone analyses, variability in SGN counts is partially explained by demographic variables such as chronological age, duration of deafness, and hearing loss etiology.…”

Section: Introductionmentioning

confidence: 99%

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Polarity Sensitivity in Pediatric and Adult Cochlear Implant Listeners

Jahn

Arenberg

2019

Trends in Hearing

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Modeling data suggest that sensitivity to the polarity of an electrical stimulus may reflect the integrity of the peripheral processes of the spiral ganglion neurons. Specifically, better sensitivity to anodic (positive) current than to cathodic (negative) current could indicate peripheral process degeneration or demyelination. The goal of this study was to characterize polarity sensitivity in pediatric and adult cochlear implant listeners (41 ears). Relationships between polarity sensitivity at threshold and (a) polarity sensitivity at suprathreshold levels, (b) age-group, (c) preimplantation duration of deafness, and (d) phoneme perception were determined. Polarity sensitivity at threshold was defined as the difference in single-channel behavioral thresholds measured in response to each of two triphasic pulses, where the central high-amplitude phase was either cathodic or anodic. Lower thresholds in response to anodic than to cathodic pulses may suggest peripheral process degeneration. On the majority of electrodes tested, threshold and suprathreshold sensitivity was lower for anodic than for cathodic stimulation; however, dynamic range was often larger for cathodic than for anodic stimulation. Polarity sensitivity did not differ between child- and adult-implanted listeners. Adults with long preimplantation durations of deafness tended to have better sensitivity to anodic pulses on channels that were estimated to interface poorly with the auditory nerve; this was not observed in the child-implanted group. Across subjects, duration of deafness predicted phoneme perception performance. The results of this study suggest that subject- and electrode-dependent differences in polarity sensitivity may assist in developing customized cochlear implant programming interventions for child- and adult-implanted listeners.

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Section: Polarity Sensitivity As a Function Of Age And Duration Of Deafnessmentioning

confidence: 72%

Section: Polarity Sensitivity As a Function Of Age And Duration Of Deafnessmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polarity Sensitivity in Pediatric and Adult Cochlear Implant Listeners

Jahn

Arenberg

2019

Trends in Hearing

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Cochlear implantation in patients with Meniere's disease: A systematic review

Desiato

Patel

Nguyen

et al. 2021

World j. otorhinolaryngol.-head neck surg.

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BackgroundMeniere's disease (MD) is an idiopathic disorder of the inner ear, which manifests as cochleo‐vestibular dysfunction. Hearing loss will progress to a profound levelin a subset of patients with MD, and vestibular interventions can independently cause loss of hearing. The aim of this study was to systematically review the published literature describing the safety and efficacy of CI in patients with MD.Materials and methodsA systematic literature review was conducted in accordance PRISMA guidelines to identify articles that assessed at least one functional outcome in patients with MD who underwent CI. Demographic information, disease history, MD symptoms, outcomes measures, and complications related to CI were extracted from included studies.ResultsIn total, 17 studies were included, and 182 patients with MD underwent CI. The weighted‐mean age was 61.9 years (range 27–85). Study objective and methodology varied, and there was significant heterogeneity in CI outcome measures reported. In total, 179 (98.3%) of 182 patients reported objective improvements in at least one hearing metric after CI. A total of 69 patients (37.9%) reported vertigo or severe dizziness prior to CI, compared to 22 patients (15.4%) postoperatively. Two studies reported significant reductions in postoperative Tinnitus Handicap Inventory score (THI). Quality of life assessments varied between studies. Complications rates were low with only nine patients (4.9%) reporting a serious CI‐related complication.ConclusionsThis systematic review evaluated 17 studies describing the safety and efficacy of CI in patients with MD and encountered many challenges due to small sample sizes, and heterogeneity in study design and outcomes measured. Despite these limitations, this study of 182 patients is to the best of our knowledge the largest systematic review evaluating the safety and efficacy of CI in MD. The results of this study support the need for a standardized approach to evaluating outcomes of CI in patients with MD in future studies.

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