Ganglion cell layer thickening in patients suffering from Obstructive Sleep Apnea–Hypopnea syndrome with long Mean Apnea–Hypopnea Duration during sleep

Chalkiadaki, Evangelia; Andreanos, Konstantinos; Karmiris, Efthymios; Florou, Chrysoula; Tsiafaki, Xanthi; Amfilochiou, Anastasia; Georgalas, Ilias; Koutsandrea, Chryssanthi; Papaconstantinou, Dimitris

doi:10.1007/s10792-020-01648-2

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Its content and items are more detailed, and it can reflect the brain cognitive function comprehensively and completely [ 8 ]. Some studies believe that MoCA is more reliable than MMSE in the detection of cognitive dysfunction in patients with OSAHS [ 9 , 10 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Effects of Obstructive Sleep Apnea-Hypopnea Syndrome and Cognitive Function in Ischemic Stroke Based on Linear Regression Equation

Kou

et al. 2022

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The objective of this research is to study the effect of obstructive sleep apnea-hypopnea syndrome on cognitive function of stroke. Based on linear regression equation and Montreal Cognitive Assessment Scale, the degree of cognitive impairment in OSAHS patients was evaluated and the influencing factors of OSAHS-induced cognitive impairment and the correlation between the degree of OSAHS and cognitive impairment were explored. The results are as follows: about 68% of OSAHS patients have cognitive dysfunction, and the incidence of cognitive dysfunction is positively correlated with OSAHS; cognitive impairment of OSAHS patients was associated with age, obesity, years of schooling, and intermittent nocturnal hypoxia or hypoventilation; the severity of cognitive dysfunction of OSAHS patients was positively correlated with age and obesity but negatively correlated with education level; Logistic regression analysis results showed that there were three factors that were finally entered into the regression equation, namely, LSaO2, BMI, and AHI, and the Logistic regression equation obtained was as follows: Logist P = − 0.109 X 1 + 0.785 X 2 + 1.228 X 3 . This study helps clinical workers to detect and intervene the impaired cognitive ability of patients with OSAHS early, so as to reduce the incidence and mortality of related complications and improve the quality of life of patients.

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Section: Literature Reviewmentioning

confidence: 99%

Effects of Obstructive Sleep Apnea-Hypopnea Syndrome and Cognitive Function in Ischemic Stroke Based on Linear Regression Equation

Kou

et al. 2022

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“…The experimental methods include (1) reporter assay, qRT-PCR with low flux and high accuracy, and (2) CLIP, microarray with high flux and low accuracy, setting low flux experimental data as strong experimental evidence and high flux experimental data as weak experimental evidence, selecting experimental databases miRTarBase and TarBase and prediction databases targetScan and miRDB, and taking the intersection of weak experimental evidence data and prediction data. The final target gene data were obtained by merging the obtained intersection genes with the strong experimental evidence data [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Expression Profile Analysis and Image Observation of miRNA in Serum of Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Shao

Shen

Chen

2021

Contrast Media & Molecular Imaging

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The expression profile and image observation of miRNA in serum of patients with obstructive sleep apnea-hypopnea syndrome were investigated. Bioinformatics methods were used to explore the molecular mechanism of obstructive sleep apnea-hypopnea syndrome (OSAHS)-related hypertension and explore the differentially expressed core miRNAs and regulatory factors, providing a theoretical basis for seeking molecular targets for clinical diagnosis and treatment. The miRNA datasets of patients with OSAHS and those with hypertension were downloaded from the public database to obtain differentially expressed miRNAs and explore the biological processes and pathways involved in the target genes. The core miRNAs and competitive endogenous RNA (ceRNA) transcription factors (TFs) were obtained by database mining and Cytoscape network analysis. The results showed that 2,579 differentially expressed miRNAs were obtained from the GSE112093 dataset. Seven upregulated miRNAs (hsa-miR-7107-5p, hsa-miR-7110-5p, hsa-miR-595, hsa-miR-1268b, hsa-miR-3064-5p, hsa-miR-68565p, and hsa-miR-1180-3p) and one downregulated miRNA (hsa-miR-22-3p) were obtained from the GSE112093 dataset. It is proved that hsa-miR-22-3p, hsa-miR-595, hsa-miR-6856-5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS.

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Retinal microcirculation characteristics in obstructive sleep apnea/hypopnea syndrome evaluated by OCT-angiography: a literature review

et al. 2022

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Ganglion cell layer thickening in patients suffering from Obstructive Sleep Apnea–Hypopnea syndrome with long Mean Apnea–Hypopnea Duration during sleep

Cited by 3 publications

References 51 publications

Effects of Obstructive Sleep Apnea-Hypopnea Syndrome and Cognitive Function in Ischemic Stroke Based on Linear Regression Equation

Effects of Obstructive Sleep Apnea-Hypopnea Syndrome and Cognitive Function in Ischemic Stroke Based on Linear Regression Equation

Expression Profile Analysis and Image Observation of miRNA in Serum of Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Retinal microcirculation characteristics in obstructive sleep apnea/hypopnea syndrome evaluated by OCT-angiography: a literature review

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