Ganglioglioma causing Intracerebral Hemorrhage

Terada, Kousaku; Uetsuhara, Koichi; Asakura, Tetsuhiko; Shimozuru, Tetsurou; Gondou, Masazumi; Sasahira, Masahiro; Ichitsubo, Hidenori

doi:10.2176/nmc.26.979

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the current results, STR + RT results in significantly better LC than STR but does not significantly improve OS. However, LC is an important endpoint, because recurrent gangliogliomas may have a malignant course, including craniospinal dissemination, or may cause neurologic symptoms (such as seizures) or intracerebral hemorrhage 45, 79, 98, 133, 134, 147‐149. In addition, locally recurrent tumors may require repeat craniotomies, which carry additional risks.…”

Section: Discussionmentioning

confidence: 99%

Value of anti–modified citrullinated vimentin and third‐generation anti–cyclic citrullinated peptide compared with second‐generation anti–cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis

Linden

Woude

Ioan‐Facsinay

et al. 2009

Arthritis & Rheumatism

148

View full text Add to dashboard Cite

Objective. Autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPAs) determined by testing with secondgeneration anti-cyclic citrullinated peptide (anti-CCP-2) are frequently measured in clinical practice because of their association with disease outcome in undifferentiated arthritis (UA) and rheumatoid arthritis (RA). Recently, 2 new ACPA tests were developed: third-generation anti-CCP (anti-CCP-3) and antimodified citrullinated vimentin (anti-MCV) autoantibody tests. To facilitate the decision on which autoantibody to test in daily practice, this study evaluated the capability of these autoantibodies and combinations of them to predict 3 outcome measures: progression from UA to RA, the rate of joint destruction in RA, and the chance of achieving sustained disease-modifying antirheumatic drug (DMARD)-free remission in RA.Methods. Patients with UA (n ‫؍‬ 625) were studied for whether UA progressed to RA after 1 year. Patients with RA (n ‫؍‬ 687) were studied for whether sustained DMARD-free remission was achieved and for the rate of joint destruction during a median followup of 5 years. Positive predictive values (PPVs) for RA development and for associations with the disease course in RA were compared between single tests (anti-CCP-2, anti-CCP-3, anti-MCV, and RF) and between combinations of these tests.Results. Among the single tests performed in patients with UA, anti-CCP-2 tended to have the highest PPV for RA development (67.1%), but the 95% confidence intervals of the other tests overlapped. Among the single tests in patients with RA, all 4 tests showed comparable associations with the rate of joint destruction and with the achievement of remission. In both ACPA-positive and ACPA-negative RA, the presence of RF was not associated with more joint destruction. For all outcome measures, performing combinations of 2 or 3 autoantibody tests did not increase the predictive accuracy compared with performing a single test.Conclusion. For clinical practice, a single autoantibody test is sufficient for risk estimation in UA and RA.Rheumatoid arthritis (RA) is considered to have an autoimmune origin because of the presence of selfreactive autoantibodies. In addition to rheumatoid facDr. van der Woude

show abstract

Section: Discussionmentioning

confidence: 99%

Value of anti–modified citrullinated vimentin and third‐generation anti–cyclic citrullinated peptide compared with second‐generation anti–cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis

Linden

Woude

Ioan‐Facsinay

et al. 2009

Arthritis & Rheumatism

148

View full text Add to dashboard Cite

show abstract

“…However, LC is an important endpoint, because recurrent gangliogliomas may have a malignant course, including craniospinal dissemination, or may cause neurologic symptoms (such as seizures) or intracerebral hemorrhage. 45,79,98,133,134,[147][148][149] In addition, locally recurrent tumors may require repeat craniotomies, which carry additional risks. Furthermore, anaplastic astrocytoma or even glioblastoma multiforme may develop at the time of recurrence.…”

Section: Discussionmentioning

confidence: 99%

The role of postoperative radiotherapy for the treatment of gangliogliomas

Rades

Zwick

Leppert

et al. 2009

Cancer

View full text Add to dashboard Cite

BACKGROUND: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma. METHODS: In 402 patients with ganglioglioma, outcomes were compared for patients who underwent gross total resection alone (GTR) (n ¼ 188), GTR plus radiotherapy (GTR þ RT) (n ¼ 21), subtotal resection alone (STR) (n ¼ 113), and STR plus RT (STR þ RT (n ¼ 80). Age, sex, tumor site, and histologic grade also were investigated. Subgroup analyses were performed for both low-grade and high-grade tumors. RESULTS: The 10-year LC rates were 89% after GTR, 90% after GTR þ RT, 52% after STR, and 65% after STR þ RT (P < .001); and the 10-year OS rates were 95%, 95%, 62%, and 74%, respectively (P < .001). After STR, irradiation significantly improved LC (P ¼ .004) but not OS (P ¼ .22). After GTR, irradiation did not significantly improve LC (P ¼ .23) or OS (P ¼ .29). On multivariate analyses, LC and OS were associated with therapy and pathologic grade, and OS also was associated with tumor site. In low-grade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .18); and, after GTR, LC (P ¼ .28) and OS (P ¼ 1.0) were not improved with postoperative radiotherapy. In highgrade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .41); after GTR, LC (P ¼ .56) and OS (P ¼ .61) were not improved with irradiation. CONCLUSIONS: According to this review, GTR should be performed whenever safely possible and does not require postoperative irradiation. If only STR is achieved, then RT improves LC of both low-grade and high-grade tumors and, thus, should be considered seriously. Cancer 2010;116:432-42.

show abstract