Ganglioglioma Arising from the Septum Pellucidum

Abstract

A 24-year-old gentleman presented to us with complaints of occasional headache for 2 years. Magnetic resonance imaging showed enhancing supra sellar mass with nonenhancing cystic components, extending superiorly up to the body of bilateral lateral ventricle, laterally displacing septum pellucidum, and compressing the third ventricle with obstructive hydrocephalus. Hormone profile depicted adrenocorticotropic hormone <5.00 pg/mL, growth hormone 1.32 ng/mL, insulin-like growth factor-1 <3.0 ng/mL. The patient underwent surgical resection. Histological finding was suggestive of ganglioglioma World Health Organization grade I. Customized immunohistochemistry panel was advised and revealed positive CD 56, NSE, and GFAP immunohistochemical stains. Gangliogliomas are less frequent neoplastic lesions confined to only a handful of case reports and studies. Accounting less than 2% of intracranial neoplasms, these lesions primarily affect those in the first 3 decades of their life. As ubiquitous it is in nature, we hereby present a case of ganglioglioma in a young adult male arising from septum pellucidum.

Intraventricular ganglioglioma: a rare case report

“…Typically, gangliogliomas present in children and young adults with focal epilepsy. They are frequently in the supratentorial compartment, most commonly in the temporal lobe [ 7 ]. However, they have also been reported to occur in the frontal, parietal and occipital lobes, as well as the brainstem, cerebellum, spinal cord, optic nerves and pineal gland.…”

“…However, they have also been reported to occur in the frontal, parietal and occipital lobes, as well as the brainstem, cerebellum, spinal cord, optic nerves and pineal gland. Gangliogliomas of the lateral ventricles are rare, with only 27 cases described in the literature, including ours [ 2 , 6 , 7 ].…”

“…It has been reported that the appearance of these tumours on MRI varies widely, with 40–70% appearing isointense and 20–40% hypointense on T1-weighted imaging. Simultaneously, on T2-weighted imaging, 20–30% of gangliogliomas appear isointense while 70–90% appear hyperintense [ 6 , 7 ]. Given this, a conclusive diagnosis of ganglioglioma cannot be made based on imaging alone.…”

“…These tumours rarely occur within the lateral ventricle. To our knowledge, there have been only 27 reported cases, including ours, of gangliogliomas in this location [ 6 , 7 ].…”