Ganglioglioma

Hirose, Takanori; Scheithauer, Bernd W.; Lopes, M. Beatriz S.; Gerber, H.; Altermatt, Hans Jörg; VandenBerg, Scott R.

doi:10.1002/(sici)1097-0142(19970301)79:5<989::aid-cncr16>3.0.co;2-z

Cited by 106 publications

(12 citation statements)

References 62 publications

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“…p53 mutations in gangliogliomas have been associated with progression toward higher WHO grades and even transformation into glioblastoma. 13–15 Previous studies have suggested that p53 mutations may be unique to higher-grade (i.e., WHO II–IV) gangliogliomas and contribute to dedifferentiation and tumor progression from WHO grade I. 13,16 However, the present case demonstrates that p53 mutations may occur in WHO grade I tumors and suggests that this finding is not necessarily associated with increased mitotic activity and malignant transformation.…”

Section: Discussioncontrasting

confidence: 53%

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

et al. 2016

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BACKGROUND Gangliogliomas are rare, low-grade intra-axial tumors that exhibit both neuronal and glial components. Although the vast majority present as an intracranial lesion, a rare subset exist as isolated lesions of the spinal cord. Gangliogliomas have also been shown to harbor mutations in the p53 tumor suppressor gene and BRAF oncogene. Previous studies in ganglioglioma have correlated p53 mutations with histologic transformation and BRAF mutations with worse prognosis. CASE DESCRIPTION In this report, we describe a 35-year-old female who presented with multifocal ganglioglioma, involving both the conus medullaris and filum terminale. The dominant lesion in the filum terminale was resected, which revealed World Health Organization I grade, p53 mutant, and BRAF wildtype status. Our study documents the first report of a multifocal ganglioglioma, originating within the spinal cord. CONCLUSIONS Importantly, this case contradicts previous reports of p53 and BRAF mutations portending worsened tumor behavior and prognosis and demonstrates that further studies are needed to delineate the role of genetic characterization in the biologic understanding and management of gangliogliomas.

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Section: Discussioncontrasting

confidence: 53%

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

et al. 2016

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“…The rare occurrence of malignant transformation is confined to the glial cell population, and is characterized by increased cellularity and mitotic activity, endothelial proliferation, and necrosis. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Ganglioglioma of the Spinal Cord

Oppenheimer

Johnson

Judkins

2015

Journal of Clinical Imaging Science

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Ganglioglioma is a rare tumor consisting of neoplastic glial and neuronal elements. It accounts for only 0.5% of all primary central nervous system (CNS) neoplasms. We report an unusual case of extensive intramedullary thoracic spinal cord ganglioglioma in a 14-month-old girl who underwent subtotal resection followed by adjuvant chemotherapy. The epidemiology, histopathologic features, imaging findings, treatment, and prognosis are subsequently reviewed.

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“…[ 1 , 2 ] Men own the predominance in gangliogliomas. [ 3 ] Most gangliogliomas are confined to temporal lobe, [ 1 , 2 , 4 ] and are the most common neuroepithelial tumors leading to long-term epilepsy. [ 5 ] The patients tend to benefit higher seizure free rates from lesionectomy.…”

Section: Introductionmentioning

confidence: 99%

Ganglioglioma of the adenohypophysis mimicking pituitary adenoma

Yuan¹,

Fang²,

Wu³

et al. 2018

Medicine

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Introduction:Ganglioglioma is a generally benign tumor, mostly occurring in patients <30 years old. Temporal lobe is most frequently involved. Up to now, only 3 cases were reported of ganglioglioma in the pituitary gland, all being confined to the neurohypophysis. Here, we are the first to report an adenohypophysis ganglioglioma.Case presentation:A 43-year-old woman presented with chronic headache was referred to our hospital. Magnetic resonance imaging (MRI) indicated pituitary adenoma. Endoscopic transnasal transsphenoidal surgery was performed. The tumor was rich in blood supply, with tough texture, therefore only subtotal resection was conducted. Pathology analysis revealed an adenohypophysial tumor composed of dysplastic ganglion cells and neoplastic glial cells collided with nonspecific hyperplasia of pituitary cells. Immunohistochemistry revealed positive staining of synaptophysin, glial-fibrillary acidic protein, and CD34. The results were consistent with the diagnosis of ganglioglioma. After the surgery the patient recovered well except developing cerebrospinal fluid rhinorrhea, which was controlled by lumbar drainage. MRI 6 months later did not show any sign of progression.Conclusion:According to the findings of our case, concerns should be raised considering ganglioglioma as a differential diagnosis of mass located in the sellar region. Furthermore, an ideal management strategy for pituitary ganglioglioma is not known; therefore, more cases and long-term follow-up are needed to enrich our knowledge of the diagnosis, treatment, and prognosis of this rare intracranial lesion.

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Ganglioglioma

Cited by 106 publications

References 62 publications

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

Ganglioglioma of the Spinal Cord

Ganglioglioma of the adenohypophysis mimicking pituitary adenoma

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