Gandouling alleviates nerve injury through PI3K/Akt/FoxO1 and Sirt1/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson's disease
Li Chen,
Wangyang Xu,
Yuting Zhang
et al.
Abstract:IntroductionPrevious studies have shown that Gandouling (GDL) may alleviate the nerve damage caused by Wilson's disease (WD) by inhibiting the autophagy of nerve cell mitochondria. However, its mechanisms are still unclear. Revealing the therapeutic mechanism of GDL is beneficial for its clinical application and provides theoretical support for the development of new formulations for treating WD.MethodThis time we found that the oxidative stress level in the body of the copper‐overloaded WD rates increased, ne… Show more
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