Abstract:of oral sildenafil therapy. Conclusions: Increased arterial inflow is the primary hemodynamic event in the development of penile erection. NO acts as a messenger molecule stimulating guanylate cyclase, and leading to the formation of cyclic guanosine monophosphate (cGMP). cGMP then acts through calcium-gated potassium channels to cause vascular smooth muscle relaxation. Phosphodiesterases (PDE) are an integral component of cyclic nucleotide signaling. PDE5 is found in high concentration within the smooth muscl… Show more
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