Gammapathies monoclonales en Tunisie : analyse épidémiologique, immunochimique et étiologique d'une série de 288 cas

Mseddi-Hdiji, S.; Haddouk, Samy; Ayed, M. Ben; Tahri, N.; Elloumi, Moez; Baklouti, S.; Hachicha, J.; Krichen, M. S.; Bahloul, Z.; Masmoudi, Hatem

doi:10.1016/j.patbio.2004.01.014

Cited by 18 publications

(16 citation statements)

References 13 publications

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“…During our 10-year study, 1579 serum immunofixations were performed, of which 782 concluded to have gammopathy with 28 cases of biclonal gammopathies, indicating an incidence of 3.5% of all gammopathies. This rate is comparable to that reported in the literature with an incidence ranging from 1% to 5% including a Tunisian study they found an incidence of 2% BG (6 cases out of 288 cases) [1][2][3].…”

Section: Discussionsupporting

confidence: 86%

“…This median age is comparable to that reported by Garcia et al, but remains lower than that described by Leroy et al,(72 years) [3,7]. There was no sex predominance in our series unlike the different series in the literature which indicates a male predominance [1][2][3].…”

Section: Discussionsupporting

confidence: 80%

“…Biclonal gammopathy is a rare condition with an incidence ranging from 1 to 5% of the patients presenting clonal plasma-cell proliferations [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco

Ghammad¹,

Berrada²,

Aissaoui³

et al. 2020

SIJB

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 80%

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Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco

Ghammad¹,

Berrada²,

Aissaoui³

et al. 2020

SIJB

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“…However, many studies have demonstrated that repeated or chronic stimulation of the immune system through autoimmune, infectious, or inflammatory disorders may lead to monoclonal gammopathy [3-5]. In our patient, MGUS was detected in combination with an uncontrolled scleral inflammation.…”

Section: Discussionmentioning

confidence: 55%

“…Monoclonal gammopathy of undetermined significance (MGUS) is a diagnosis given to patients with monoclonal gammopathy who have no features of multiple myeloma or other malignant disorders. Although the etiology of monoclonal gammopathy is not exactly known, it has been suggested that this condition is associated with chronic inflammation and infection [3-5]. Moreover, patients with monoclonal gammopathy have decreased productions of normal immunoglobulins and experience overall suppression of the immune system.…”

mentioning

confidence: 99%

Aspergillus fumigatus Scleritis Associated with Monoclonal Gammopathy of Undetermined Significance

Kim

et al. 2010

Korean J Ophthalmol

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A 68-year-old woman presented with pain in her left eye. Necrosis with calcium plaques was observed on the medial part of the sclera. Aspergillus fumigatus was isolated from the culture of the necrotic area. On systemic work-up including serum and urine electrophoresis studies, the serum monoclonal protein of immunoglobulin G was detected. The patient was diagnosed with monoclonal gammopathy of undetermined significance and fungal scleritis. Despite intensive treatment with topical and oral antifungal agents, scleral inflammation and ulceration progressed, and scleral perforation and endophthalmitis developed. Debridement, antifungal irrigation, and tectonic scleral grafting were performed. The patient underwent a combined pars plana vitrectomy with an intravitreal injection of an antifungal agent. However, scleral and intraocular inflammation progressed, and the eye was enucleated. Aspergillus fumigatus was isolated from the cultures of the eviscerated materials. Giemsa staining of the excised sclera showed numerous fungal hyphae.

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Epidemiology of monoclonal gammopathy in Morocco – A hospital‐based study

et al. 2023

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Background Monoclonal gammopathies are a group of disorders associated with clonal proliferation of plasma cells that produces a monoclonal protein. Aims The main objective of this study was to describe the epidemiological and immunochemical characteristics of monoclonal gammopathies diagnosed during 19 years in a Moroccan teaching hospital. Materials and Results This retrospective study enrolled 443 Moroccan patients with monoclonal gammopathy, patients meeting the inclusion and exclusion criteria in at the biochemistry department of Military Hospital in Rabat, the capital of Morocco, from January 2000 to August 2019. Of the 443 enrolled patients, 320 (72.23%) were men and 123 (27.77%) were women. All patients were of Caucasian origin, from 12 Moroccan regions. The patient's samples were collected and subjected to serum protein electrophoresis and serum immunofixation electrophoresis to further characterize the monoclonal protein. The mean ± SD age of the 443 participants was 62.24 ± 13.14 years. Reasons for being admitted to the hospital were as follows, bone pain (41.60%), renal failure (19.08%), alteration of the general condition (12.21%), and anemia (10.69). Plasma cell proliferative disorders in our study were as follows, multiple myeloma (MM) (45.65%), Monoclonal gammopathies of undetermined significance (MGUS) (39.05%), Waldenstrom's macroglobulinemia (5.58%), Lymphoma (2.27% + 1.2%), Chronic Lymphocytic Leukemia (2.48%), Plasma cell leukemia (1.86%), Plasmacytoma (0.62%), POEMS syndrome (0.41%), and Amyloidosis (0.84%). The most frequent isotypes in MM were the IgGκ (62) 36.5%, IgGλ (52) 30.6%, IgAκ (27) 15.9%, and the IgAλ (19) 11.2%. It is also worth noting that Free light chain MM represents 20% of all cases of MM. Conclusions We found that monoclonal gammopathies are age‐related and affects men more than women, also the results of this study point to the delayed diagnosis of monoclonal gammopathies, since most of our patients were diagnosed at the MM stage. The most frequent isotypes were the IgGκ and IgGλ in MM and MGUS, in Waldenström macroglobulinemia were IgMκ and IgMλ and the oligoclonal profile represented only 3.70%.

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Gammapathies monoclonales en Tunisie : analyse épidémiologique, immunochimique et étiologique d'une série de 288 cas

Cited by 18 publications

References 13 publications

Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco

Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco

Aspergillus fumigatus Scleritis Associated with Monoclonal Gammopathy of Undetermined Significance

Epidemiology of monoclonal gammopathy in Morocco – A hospital‐based study

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