Gammagrafía con 75SeHCAT en la diarrea crónica por malabsorción de ácidos biliares

Bares, L.M. Mena; Asenjo, Elvira Carmona; Sánchez, M.V. García; Ortega, E. Moreno; Muret, F.R. Maza; Moreno, M.V. Guiote; Bueno, A.M. Santos; Flores, Eva Iglesias; Cantero, J.M. Benítez; Casas, J.A. Vallejo

doi:10.1016/j.remn.2016.08.005

Cited by 8 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the high prevalence of BAM in FD and IBS-D, the SeHCAT test should be performed in chronic diarrhea with functional characteristics after evaluating FBC, CRP, coeliac serology, thyroid function, and stool exams (calprotectin, coproculture, ova, and parasites) [54, 55]. However, up to now, its cost and the lack of an agreed standard cutoff have strongly limited its wider acceptance and availability in everyday clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Fani

Bertani

Paglianiti

et al. 2018

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. The SeHCAT test provides a quantitative assessment to estimate the severity of BAM and the possible response to therapy with bile acid sequestrants (BASs). However, there is no general agreement regarding its cutoff value and the test is not widely available. The aim of this review is to discuss the advantages and disadvantages of the SeHCAT test in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Fani

Bertani

Paglianiti

et al. 2018

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…The gold standard for the diagnosis of BAM is the 75 SeHCAT test, not widely available; it has a high cost and many countries, including the US, have not implemented it [ 52 ]. Studies carried out for the determination of BAM in patients with CD and ileocolonic resection showed a reduction in retention of SeHCAT with an increase in the proportion of BAs lost in the feces [ 53 ]; in serum, however, the total BA pool remains stable until the ileal resection, or when the intestinal inflammation is limited to a shorter tract of intestine and the liver, despite an increased synthesis, is no longer able to compensate for the fecal loss of BAs [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Role of bile acids in inflammatory bowel disease

Tiratterra

Franco

Porru

et al. 2018

aog

View full text Add to dashboard Cite

Bile acids (BAs) are the end product of cholesterol catabolism. Their synthesis is regulated by the nuclear receptor farnesoid X receptor, also involved in the control of their enterohepatic circulation. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial diseases characterized by diarrhea. The pathogenesis of diarrhea in IBD is still debated. The most important factor is the inflammatory process of the intestinal wall, causing alterations of solute and water absorption/secretion, deterioration of epithelial cell integrity, disruption of the intestinal microflora homeostasis, and impairment of specific transport mechanisms within the gut (including that of BAs). In this review, we summarize the current state of the art in this area and we critically evaluate the alterations of BA metabolism in patients with CD and UC.

show abstract

Gammagrafía con 75Se-ácido tauroselcólico (75SeHCAT®), ¿prueba de referencia en la malabsorción de ácidos biliares?

García

Palma

Martínez

et al. 2019

Revista Española de Medicina Nuclear e Imagen Molecular

View full text Add to dashboard Cite

Gammagrafía con 75SeHCAT en la diarrea crónica por malabsorción de ácidos biliares

Cited by 8 publications

References 51 publications

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Role of bile acids in inflammatory bowel disease

Gammagrafía con 75Se-ácido tauroselcólico (75SeHCAT®), ¿prueba de referencia en la malabsorción de ácidos biliares?

Contact Info

Product

Resources

About