Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease

Zhen, Junli; Qian, Yafang; Weng, Xiechuan; Su, Wenting; Zhang, Jianliang; Cai, Lihui; Dong, Lin; An, Haiting; Su, Ruijun; Wang, Jiang; Zheng, Yi; Wang, Xiaomin

doi:10.1016/j.trci.2017.07.002

Cited by 43 publications

(27 citation statements)

References 54 publications

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“…The 5XFAD model allows for an accelerated timetable of cognitive dysfunction associated with Aβ-related AD pathology in comparison to the Tg2576 model [34,35] which was used in our prior studies. 5XFAD mice show impaired remote memory stabilization prior to four months of age [49]; impaired spatial memory in the Y-maze at 4-5 months of age [35], Morris water maze at six months of age [50,51], and radial water maze at eight months of age [52]; decreased working memory and learning during NORT testing at six months of age [50]; and decreased contextual fear memory by six months of age [38,49,53]. We tested object recall (NORT) and contextual fear (CFR) memory of approximately 8-9 month old female and male 5XFAD mice and WT littermates treated with CAW for 3-4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

et al. 2019

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Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive benefits. We have reported that CA water extract (CAW) treatment improves cognitive function of aged Alzheimer’s disease (AD) model Tg2576 and wild-type (WT) mice, and induces an NRF2-regulated antioxidant response in aged WT mice. Here, CAW was administered to AD model 5XFAD female and male mice and WT littermates (age: 7.6 +/ − 0.6 months), and object recall and contextual fear memory were tested after three weeks treatment. CAW’s impact on amyloid-β plaque burden, and markers of neuronal oxidative stress and synaptic density, was assessed after five weeks treatment. CAW antioxidant activity was evaluated via nuclear transcription factor (erythroid-derived 2)-like 2 (NRF2) and NRF2-regulated antioxidant response element gene expression. Memory improvement in both genders and genotypes was associated with dose-dependent CAW treatment without affecting plaque burden, and marginally increased synaptic density markers in the hippocampus and prefrontal cortex. CAW treatment increased Nrf2 in hippocampus and other NRF2 targets (heme oxygenase-1, NAD(P)H quinone dehydrogenase 1, glutamate-cysteine ligase catalytic subunit). Reduced plaque-associated SOD1, an indicator of oxidative stress, was observed in the hippocampi and cortices of CAW-treated 5XFAD mice. We postulate that CAW treatment leads to reduced oxidative stress, contributing to improved neuronal health and cognition.

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Section: Discussionmentioning

confidence: 99%

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

et al. 2019

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“…In contrast, deep-brain reachable low field magnetic stimulation (DMS) produces a magnetic field with high output frequency, low intensity, and wide range that can stimulate deeper brain regions such as the hippocampus (7). DMS stimulates the brain by emitting electromagnetic fields, similar to those produced by echo planar magnetic resonance imaging (8).…”

Section: Introductionmentioning

confidence: 99%

“…Low field magnetic stimulation produced rapid improvements in mood in depressed patients in a randomized controlled study (9), which could be mediated by increasing brain-derived neurotrophic factor (BDNF) levels (10). DMS has also been shown to improve cognitive function in a transgenic mouse model of Alzheimer's disease (7). In this study, we sought to investigate the possible impact of DMS on schizophrenia-related features in a mouse model that simulates white matter and connectivity deficits of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Low Field Magnetic Stimulation Ameliorates Schizophrenia-Like Behavior and Up-Regulates Neuregulin-1 Expression in a Mouse Model of Cuprizone-Induced Demyelination

Sun

Jiang

et al. 2018

Front. Psychiatry

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White matter and myelin sheath integrity are disrupted in schizophrenia, and non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach. In particular, deep-brain reachable low field magnetic stimulation (DMS) could alleviate cognitive impairment and depressive-like behaviors in animal models. In this study, we sought to assess the effects of DMS on myelin sheath damage and schizophrenia-like behaviors in the cuprizone-induced demyelination mouse model. Mice were fed cuprizone (copper ion chelating agent, 0.2% w/w mixed with food) for 6 weeks to induce demyelination. During these 6 weeks, mice were stimulated with either sham, low-frequency (LFS, delta frequency) DMS or high-frequency (HFS, gamma Hz) DMS for 20 min each day. Behavioral tests were conducted 24 h after the final DMS session. The myelin sheath was examined by immunohistochemistry and the expression of neuregulin-1 (NRG1)/ErbB4 in the prefrontal cortex was measured with Western blotting. Six weeks of HFS significantly alleviated schizophrenia-like behaviors in cuprizone mice, including improved nesting, social interaction and sensorimotor gating, while LFS improved sensorimotor gating only. HFS and LFS both repaired the myelin sheath and increased the expression of neuregulin-1 and its receptor ErbB4, in the prefrontal cortex of demyelinated mice. Our findings show that DMS is a potential effective neuromodulation technique for the treatment of schizophrenia. One possible mechanism underlying these therapeutic effects could involve the up-regulation of NRG1/ErbB4 signaling in the prefrontal cortex.

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“…The process of preparing acute brain slices were similar to those described previously [29,30]. Mice were sacri ced by decapitation after anesthesia with pentobarbital sodium (30 mg/kg).…”

Section: Extracellular Multichannel Electrophysiologymentioning

confidence: 99%

Electro-acupuncture alleviates motor deficits and maladaptive striatal plasticity in partial-lesioned parkinsonian mice

Su¹,

Yu²,

Li³

et al. 2020

Preprint

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Background Parkinson's disease is characterized by abnormal synaptic transmission in the corticostriatal circuit that leads to deficits in motor abilities. Electro-acupuncture has shown to improve the motor behaviors in parkinsonian models. However, the potential mechanisms underlying the electro-acupuncture treatment, specifically in the partial-lesioned model, remain unclear. Methods By utilizing multiple approaches, including electrophysiological, immunohistochemistrical, molecular and behavioral methods, we assessed the effect of electro-acupuncture on the motor dysfunction and striatal synaptic plasticity in a partial-lesioned mouse model induced by intrastriatal injection of 6-hydroxydopamine. Results Electro-acupuncture ameliorated the disrupted gross and fine motor skills in 6-hydroxydopamine-lesioned mice. Notably, electro-acupuncture not only restored the injured corticostriatal long-term potentiation, but also reversed the loss of GluN1-containing NMDA receptors and GluA1-containing AMPA receptors in the striatum. Furthermore, the antagonists selective for AMPA receptors and NMDA receptors blocked the effect of electro-acupuncture on the corticostriatal long-term potentiation in 6-hydroxydopamine-treated mice. Conclusions These data suggest that the postsynaptic glutamate receptors in the striatum undergo the maladaptive changes in the early stage of Parkinson's disease. Electro-acupuncture improves the motor skills via a mechanism involving the modulation of corticostriatal synaptic plasticity and specific glutamate receptors in a partial-lesioned rodent model.

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Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease

Cited by 43 publications

References 54 publications

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Low Field Magnetic Stimulation Ameliorates Schizophrenia-Like Behavior and Up-Regulates Neuregulin-1 Expression in a Mouse Model of Cuprizone-Induced Demyelination

Electro-acupuncture alleviates motor deficits and maladaptive striatal plasticity in partial-lesioned parkinsonian mice

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